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Abstract
Purpose Renal ischemia–reperfusion (I/R), an important
cause of acute kidney injury, is unavoidable during various
types of operations, including renal transplantation, surgical
revascularization of the renal artery, partial nephrectomy,
and treatment of suprarenal aortic aneurysms.
Exacerbation of I/R injury is mediated by reactive oxygen
species (ROS). A recent study has shown that hydrogen has
antioxidant properties. In this study, we tested the
hypothesis that a hydrogen-rich saline solution (HRSS)
attenuates renal I/R injury in a rodent model.
Methods Rats were treated with an intravenous injection
of HRSS or control saline solution followed by renal I/R.
After 24 h of treatment, we performed a histological
examination and transmission electron microscopy, and
measured serum levels of 8-OHdG.
Results Histological analysis revealed a marked reduction
of interstitial congestion, edema, inflammation, and hemorrhage
in renal tissue harvested 24 h after HRSS treatment
compared to saline administration. Renal I/R injury, which
led to altered mitochondrial morphology, was also inhibited
by HRSS. Furthermore, serum 8-OHdG levels were
significantly lower in rats treated with HRSS and subjected
to renal I/R.

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