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鍘熻姳闈掔礌鍦ㄨ惀鍏诲涓鍙楀叧娉紝灏ゅ叾鍦ㄨタ鏂归ギ椋熶腑锛屽洜涓哄畠鍗犱汉浠憚鍏ラ叜绫讳腑鐨勪竴澶ч儴鍒嗭紝瀵逛汉浣撳仴搴峰緢鏈夊府鍔┿€傜劧鑰屼汉浠粛涓嶆槸寰堟竻妤氬湪浣撳唴鍙戞尌鏈夌泭浣滅敤鐨勭┒绔熸槸鍘熻姳闈掔礌鐨勫崟浣撱€佷綆鑱氫綋锛岃繕鏄偁閬撳井鐢熺墿鐨勮姵棣欐棌閰哥殑琛嶇敓鐗┿€傚洿缁曡繖涓簤璁猴紝Garcia绛塠4]鐢ㄤ竴绉嶅悎鎴愮殑浣庤仛鍘熻姳闈掔礌(鍖呭惈鐢变箼鍩烘ˉ鑱旂殑琛ㄥ効鑼剁礌鍗曚綅)鍠傚吇闆勬€istar澶ч紶(200 mg/kg浣撻噸)锛岃繖绉嶅悎鎴愮殑鍘熻姳闈掔礌(synthetic PC 锛孲PC)杩樺寘鎷簩鑱氫綋銆佷笁鑱氫綋銆佸洓鑱氫綋銆傞鍏?h鍚庯紝鍦ㄨ娴嗕腑妫€娴嬪嚭鍥涚敳鍩哄寲浜岃仛浣撳師鑺遍潚绱?TDPC)锛岄鐢?h鍚庯紝琛€娴嗕腑杈炬渶楂樻祿搴?14 mg/L)锛屽悓鏃惰倽鑴忎腑姣忓厠缁勭粐涓篃鍚湁15 mug鐨凾DPC銆傜爺绌惰〃鏄庯紝鍙ｆ湇浜岃仛浣撳師鑺遍潚绱犺兘寰堝揩鍚告敹锛屽苟鍦ㄤ綋鍐呯敳鍩哄寲銆傝瀹為獙鏄娆″湪琛€娴嗗拰鑲濊剰涓娴嬪嚭鐢插熀鍖栫殑浜岃仛浣撳師鑺遍潚绱犮€侴arcia绛夎涓猴紝琛€娴嗗拰鑲濊剰涓殑TDPC鍙戞尌浜嗘縺绱犳牱鏁堝簲锛屼笖鍦ㄥ師鑺遍潚绱犲拰瀵屽惈鍘熻姳闈掔礌鐨勯鐗╀腑锛屽師鑺遍潚绱犱簩鑱氫綋鏄渶浣崇殑鐢熺墿娲绘€х墿璐ㄣ€傚湪Shoji绛塠5]鍒嗘瀽鑻规灉鍘熻姳闈掔礌鐨勫惛鏀舵儏鍐垫椂涔熻瘉瀹炰簡鍘熻姳闈掔礌浣庤仛浣撹兘寰堝揩琚ぇ榧犲惛鏀讹紝鐩存帴鍙備笌浣撳唴鐨勭敓鐞嗗姛鑳斤紝涓斿鑱氫綋鍘熻姳闈掔礌褰卞搷浣庤仛浣撶殑鍚告敹銆?Tsang绛塠6]灏嗚憽钀勭苯鎻愬彇鐗╁寘鎷効鑼剁礌銆佽〃鍎胯尪绱狅紝鍘熻姳闈掔礌鐨勪簩鑱氫綋銆佷笁鑱氫綋銆佸洓鑱氫綋鍜屽鑱氫綋鍠傚吇澶ч紶锛?4h鍚庢娴嬭倽銆佽偩銆佽剳鍜岃儍鑲犻亾浠ュ強鏀堕泦琛€娴嗐€佸翱鍜屾帓娉勭墿锛岄珮鏁堟恫鐩歌壊璋辨硶鍒嗘瀽瀹冧滑鐨勯粍鐑?3-閱囧惈閲忋€傞鍏?h鍚庯紝灏戦噺鐨勯粍鐑?3-閱囦粠鑳冩帓绌哄埌鍗佷簩鎸囪偁锛屽緢澶х▼搴﹀湴鍒拌揪鍥炶偁锛?h鍚庤繘鍏ョ洸鑲狅紝3h鍚庢湁鐩稿杈冨皯閲忕殑琚娴嬪埌杩涘叆缁撹偁銆傝儍鑲犻亾锛屼互鍙婅儍鑲犲鐨勮憽钀勭苯鎻愬彇鐗╅粍鐑?3-閱囧拰浠呰兘绀鸿釜鐨勫師鑺遍潚绱狅紝杩樹笉鑳借瘉鏄庡師鑺遍潚绱犳槸鍦ㄨ儍鑲犻亾瑙ｈ仛閲婃斁鍑洪粍鐑?3-閱囥€傜壒鍒槸鍦ㄨ娴嗕腑鍚湁杈冨鐨勫効鑼剁礌钁＄硸鑻烽吀鍜岀敳鍩哄寲钁＄硸鑻烽吀浠ｈ阿浜х墿锛屽湪鑲濄€佽偩涓篃妫€娴嬪埌杩欎簺鐗╄祫锛屽翱娑蹭腑涔熻〃鐜版湁杩欎簺鐗╄祫浠ュ強纭吀鐩愪唬璋㈢墿锛屽拰灏戦噺鍘熻姳闈掔礌浜岃仛浣揃1锛?B2锛?B3 鍜孊4锛屼互鍙婁笁鑱氫綋C2鍜屾湭鐭ョ殑鍘熻姳闈掔礌涓夎仛浣撱€?4h鍚庡湪灏挎恫涓娴嬪嚭鐨勫効鑼剁礌鍜岃〃鍎胯尪绱犱唬璋㈢墿鐨勯噺鍒嗗埆鏄憚鍏ュ崟浣撻噺鐨?7% 鍜?6 %锛屾姘村钩涓庡叾浠栫爺绌惰€呮姤鍛婄殑缁撴灉涔熺浉涓€鑷达紝璇ョ粨鏋滄樉绀猴紝钁¤悇绫芥彁鍙栫墿涓殑鍘熻姳闈掔礌浣庤仛鐗╅鍏ュ悗鍦ㄤ换浣曠▼搴︿笂娌℃湁瑙ｈ仛鎴愬崟浣撳舰寮忋€傝繕娌℃湁鍏呭垎鐨勫垎鏋愭暟鎹兘璇佹槑鍦ㄨ剳涓湁榛勭兎-3-閱囦唬璋㈢墿瀛樺湪銆?/font>
璁稿鐮旂┒璇佹槑锛屽師鑺遍潚绱犲叿鏈夊緢寮虹殑鎶楁哀鍖栨椿鎬э紝鏄竴绉嶅緢濂界殑姘ц嚜鐢卞熀娓呴櫎鍓傚拰鑴傝川杩囨哀鍖栨姂鍒跺墏銆侭agchi绛塠7]鐢ㄥ皬榧犺繘琛屼綋鍐呭疄楠岋紝鐢ㄨ憽钀勭苯鎻愬彇鐗╁師鑺遍潚绱犮€乂C銆乂E鐞ョ弨閰哥洂(VES),β-鑳¤悵鍗滅礌瀵筎PA(12-O-tetradecanoylphorbol-13-acetate 锛?2-O-鍗佸洓鐑烽叞浣涙尝閱?13-閱嬮吀鐩?璇卞鐨勮倽銆佽剳缁勭粐涓剛璐ㄨ繃姘у寲鐨勪繚鎶や綔鐢ㄨ繘琛屼簡姣旇緝锛屽彂鐜板湪100 mg/kg BW鍓傞噺涓嬪師鑺遍潚绱犮€乂C銆乂ES銆?beta;-鑳¤悵鍗滅礌鍧囧彲闄嶄綆TPA璇卞浜х敓鐨勬椿鎬ф哀绨囷紝浣跨敤鑵硅厰宸ㄥ櫖缁嗚優鍙戝厜娉曢檷浣庣巼鍒嗗埆涓?0锛呫€?8锛呫€?7锛呭拰16锛咃紝浣跨敤缁嗚優鑹茬礌杩樺師娉曢檷浣庣巼鍒嗗埆涓?5锛?銆?5锛呫€?7锛呭拰19锛咃紝鍚屾椂杩樺彂鐜板師鑺遍潚绱犲浜庢姂鍒禩PA璇卞鐨勮剛璐ㄨ繃姘у寲鍙嶅簲浠ュ強鑵硅厰宸ㄥ櫖缁嗚優娲绘€ф哀鐨勪骇鐢燂紝鍏锋湁鍓傞噺鍙嶅簲鍏崇郴銆傜粨鏋滆〃鏄庯紝钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌鍙姘у寲鎹熶激璧峰埌淇濇姢浣滅敤锛屼笖淇濇姢浣滅敤浼樹簬鍏跺畠鎶楁哀鍖栧墏銆傛澶栵紝Bagchi绛塠8]鐨勪綋澶栬瘯楠屼篃鑾峰緱浜嗙浉浼肩殑缁撴灉銆傛垜浠垎鍒娇鐢ㄥ寲瀛﹀彂鍏夋硶鍜岀粏鑳炶壊绱燙杩樺師娉曟祴瀹氫簡钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌銆乂C銆乂E娓呴櫎瓒呮哀闃寸瀛愯嚜鐢卞熀鍜岀緹鍩鸿嚜鐢卞熀鐨勮兘鍔涖€傜粨鏋滆〃鏄庯紝鍘熻姳闈掔礌瀵硅嚜鐢卞熀鐨勬姂鍒跺叿鏈夋祿搴﹀弽搴斿叧绯伙紝鍦?00mg/L鐨勬祿搴︽椂锛屽師鑺遍潚绱犲瓒呮哀鍖栭槾绂诲瓙鍜岀緹鍩鸿嚜鐢卞熀鐨勬姂鍒惰兘鍔涘垎鍒负78锛呭拰81锛咃紱鍚岀瓑鏉′欢涓嬶紝VC鎶戝埗涓婅堪涓ょ鑷敱鍩虹殑鑳藉姏鍒嗗埆涓?2锛呭拰19锛咃紝VE涓?0锛呭拰75锛咃紝璇存槑鍘熻姳闈掔礌鏄竴绉嶆瘮VC銆乂E鏇村己鐨勮嚜鐢卞熀娓呴櫎鍓傘€?/font>
Simonetti绛塠9]璇勪环浣撳琛ュ厖钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌瀵规湁姘у寲搴旀縺鑰呯殑褰卞搷锛?0鍚嶅仴搴疯嚜鎰胯€呮瘡鏃ュ彛鏈?10mg鍘熻姳闈掔礌30d锛屾湇鐢ㄥ墠鍚庢娊鍙栭潤鑴夎锛屾瘮杈冨彂鐜帮紝鎬绘姉姘у寲鑳藉姏浠ュ強琛€娴嗕腑α-鐢熻偛閰氭祿搴︽病鏈夋敼鍙橈紝鑰岀孩缁嗚優鑶滀腑α-鐢熻偛閰氭祿搴︿粠1.8±0.1 澧炲姞鍒?.8±0.2 mg/g锛孌NA琚哀鍖栫殑娣嬪反缁嗚優浠?.23±2.47 鍑忓皯鍒?.34±0.51锛屽苟涓旂孩缁嗚優鑶滀腑鑴傝偑閰哥殑鏋勬垚鍙樹负楂樻按骞崇殑涓嶉ケ鍜岃剛鑲吀銆傜粨鏋滆〃鏄庯紝鏈嶇敤鍘熻姳闈掔礌鍙彂鎸ュ湪浣撳唴鐨勬姉姘у寲淇濇姢浣滅敤锛屽彲鑺傜害浣撳唴鑴傛憾鎬х淮鐢熺礌E锛屽噺灏戞穻宸寸粏鑳濪NA鐨勬哀鍖栨崯浼ゃ€侼uttall绛塠10]閫氳繃涓村簥鐮旂┒钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌瀵硅娴嗘€绘姉姘у寲鑳藉姏(TAC)銆乂C銆乂E姘村钩鐨勫奖鍝嶏紝瀵?0浣嶈嚜鎰胯€呴噰鍙栭殢鏈哄崟鐩层€佸畨鎱板墏瀵圭収鐮旂┒锛岃鍙楄瘯鑰呮湇鐢ㄥ惈300mg鍘熻姳闈掔礌鐨勮兌鍥?棰楁垨瀹夋叞鍓傝繛缁?d锛?d鍚庨噰闆嗚鏍凤紝闂撮殧鑷冲皯2wk鍚庨噸澶嶇爺绌躲€傜粨鏋滄樉绀猴紝琛€娴嗕腑VC銆乂E鐨勫惈閲忔病鏈夊彉鍖栵紝鑰孴AC姘村钩鎻愰珮锛岀5d鏃讹紝TAC浠?08.1±22.9 鎻愰珮鍒?53.3±453.3銆傜爺绌惰〃鏄庯紝钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌鑳芥彁楂樿娴員AC锛屼絾鍏朵复搴婂簲鐢ㄨ繕闇€杩涗竴姝ラ殢鏈哄疄楠岀爺绌躲€?/font>
璁稿鍘熷彂鎬с€佽繘灞曟€ч€€琛屾€х柧鐥呰璁や负涓庤繃搴︾殑杩囨哀鍖栧弽搴旀湁鍏筹紝Zhu绛塠11]鐮旂┒浜嗕粠鍙彲鎻愬彇鐗╁効鑼剁礌銆佽〃鍎胯尪绱犮€佸師鑺遍潚绱犱綆鑱氱墿瀵硅嚜鐢卞熀寮曡捣鐨勫皬榧犵孩缁嗚優婧惰鐨勫奖鍝嶏紝浣撳鐮旂┒鍙戠幇锛屽効鑼剁礌銆佽〃鍎胯尪绱犮€佸師鑺遍潚绱犱綆鑱氱墿鍦?.5~40μmol/L鏃跺瓨鍦ㄥ墏閲忎緷璧栨€т繚鎶や綔鐢紝鍏朵腑浜岃仛浣撱€佷笁鑱氫綋銆佸洓鑱氫綋琛ㄧ幇鍑烘渶寮虹殑鎶戝埗浣滅敤锛?0μmol/L鏃讹紝瀵规憾琛€鎶戝埗鐜囧垎鍒槸59.4%锛?66.2%锛?70.9%锛?0 μmol/L鏃讹紝84.1%锛?87.6%锛?81.0%锛?40μmol/L鏃讹紝90.2%锛?88.9%锛?78.6%銆備箣鍚庤繘涓€姝ョ爺绌讹紝A缁勶細鐢?00mg鍘熻姳闈掔礌缁欏皬榧犵亴鑳冿紱B缁勶細瀵圭収缁勶紝鐏岀敓鐞嗙洂姘淬€傛祴琛€娴嗘€绘姉姘у寲鑳藉姏锛屽彂鐜癆缁勭亴鑳冨悗30~240min鏃惰娴嗘姉姘у寲鑳藉姏鏄庢樉鎻愰珮 (P < 0.05)锛岀孩缁嗚優鎶楁憾琛€鑳藉姏澧炲己(P < 0.05)銆傚悓鏃跺皢A缁勫皬榧犵殑绾㈢粏鑳炰笌B缁勫皬榧犵殑琛€娴嗘贩鍜岋紝鍙戠幇A缁勫皬榧犵孩缁嗚優鐨勬姉婧惰鑳藉姏澧炲己锛涘皢A缁勫皬榧犵殑琛€娴嗕笌B缁勫皬榧犵殑绾㈢粏鑳炴贩鍚堬紝鍙戠幇B缁勫皬榧犵殑绾㈢粏鑳炴姉婧惰鑳藉姏涔熷寮恒€傜粨鏋滆〃鏄庯紝鍙彁鍙栫墿鍎胯尪绱犮€佽〃鍎胯尪绱犮€佸師鑺遍潚绱犱綆鑱氱墿鍏锋湁寰堝己鐨勭粏鑳炶啘淇濇姢浣滅敤銆?Roychowdhury绛塠12]閫氳繃浣撳缁嗚優鍩瑰吇鐮旂┒钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌瀵圭缁忓皬鑳惰川缁嗚優姘у寲搴旀縺鐨勪繚鎶や綔鐢紝缁撴灉鏄剧ず锛岀敤50mg/L鐨勫師鑺遍潚绱犲鐞嗚繃鐨勭缁忓皬鑳惰川缁嗚優瀵笻2O2鐨勮€愬彈鎬ф彁楂橈紝鍒嗘瀽琛ㄦ槑锛屽師鑺遍潚绱犲噺浣庝簡绁炵粡灏忚兌璐ㄧ粏鑳炲唴NO鐨勪骇鐢燂紝鍚屾椂锛屽湪NO浜х敓鏃讹紝钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌鍙彁渚涘缁嗚優鍐匞SH(杩樺師鍨嬭胺鍏夎嫹鑲?鐨勪繚鎶や綔鐢紝鍥犺€屾彁楂樹簡H2O2鎹熶激鍚庣粏鑳炵殑娲绘€с€侺u绛塠13]閫氳繃鑷寸檶鐗╄川PMA (phorbol-12-myristate-13-acetate锛?2-鍗佸洓閰镐經娉㈤叝-13-涔欓吀鐩?鎹熶激妯″瀷鐮旂┒钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌瀵硅倽缁嗚優鐨勪繚鎶や綔鐢紝鍗曠粏鑳炲嚌鑳剁數娉虫樉绀猴紝鍘熻姳闈掔礌鑳芥湁鏁堜繚鎶MA寮曡捣鐨凞NA鎹熶激锛屾姂鍒禤MA浠嬪鐨凥2O2浜х敓锛屽彟澶栬繕鍙姂鍒惰倽绾跨矑浣撹剛璐ㄨ繃姘у寲鍙嶅簲锛屼繚鎶よ倽绾跨矑浣揝OD(瓒呮哀鍖栫墿姝у寲閰?娲绘€у強闄嶄綆MDA(涓欎簩閱?鐨勫惈閲忋€侺i绛塠14]杩樺皢钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌瀵规哀鍖栨崯浼ゅ悗鐨勭粏鑳炵殑绋嬪簭鎬ф浜″強绾跨矑浣撹法鑶滅數浣嶇殑褰卞搷杩涜鐮旂┒锛屽皢绂讳綋澶ч紶鑳歌吅缁嗚優H2O2鎹熶激鍚庯紝娴佸紡缁嗚優璁￠噺娉曟娴嬶紝缁嗚優绋嬪簭鎬ф浜″強绾跨矑浣撹法鑶滅數浣嶅垎鍒槸(29.53±3.8) %鍜?27.24±2.2) %锛岀敤娴撳害涓?0mg/L鐨勫師鑺遍潚绱犲鐞嗗悗锛屾娴嬪€煎垎鍒槸(8.61±1.2)%鍜?87.55±4.7) %锛屼袱瀹為獙缁勫樊鍒湁鏄捐憲鎬?琛ㄦ槑钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌鑳芥姂鍒舵哀鑷敱鍩烘崯浼ゅ悗鐨勭粏鑳炵▼搴忔€ф浜″強闄嶄綆绾跨矑浣撹法鑶滅數浣嶃€?/font>
鍘熻姳闈掔礌鑳戒笌铔嬬櫧缁撳悎骞舵敼鍙樺叾缁撴瀯锛屽洜鑰岃兘璋冭妭浠ｈ阿閫斿緞涓叧閿叾鍜岃泲鐧芥椿鎬с€傚彟澶栧師鑺遍潚绱犲奖鍝嶆哀鍖栬繕鍘熷弽搴旀晱鎰熺殑淇″彿浼犲閫斿緞锛屾敼鍙樺叾鍩哄洜琛ㄨ揪[9]銆侾uiggros绛塠15] 璇勪环浜嗚憽钀勭苯鎻愬彇鐗╁師鑺遍潚绱犲鑲濈檶缁嗚優鏍狧epG2鐨勪綔鐢ㄦ晥鏋滐紝RT-PCR鍜屽垎鍏夊厜搴︽硶娴嬭瘯mRNA鍜岄叾娲绘€ф按骞炽€傚湪姘у寲鐘舵€佷笅(1mmH2O2锛?h)锛岀檶缁嗚優鐨凣SH(杩樺師鍨嬭胺鍏夎嫹鑲?鍚噺涓嬮檷锛孧DA鍚噺鍗囬珮锛岀敱浜嶨Px/GR(璋峰厜鑻疯偨杩囨哀鍖栫墿閰?璋峰厜鑻疯偨杩樺師閰?mRNAs鐨勫悗璋冩帶璋冭妭鍙奊STmRNA鐨勮皟鑺傚寮烘墍鑷淬€傜敤钁¤悇绫芥彁鍙栫墿鍘熻姳闈掔礌澶勭悊(15mg/L锛?4h)鍚庣殑瀹為獙缁勪笌姘у寲缁勭浉姣旓紝GPx/GR琛ㄨ揪澧炲姞锛孏SH鍚噺涓庢哀鍖栫粍鏃犳樉钁楀樊寮傦紝涓擥Px/GR閰剁殑娲绘€ф病鏈夋槑鏄惧鍔犮€傜爺绌惰€呭垎鏋愶紝鍦ㄦ祿搴︿负15mg/L鏃跺師鑺遍潚绱犱富瑕侀€氳繃澧炲己mRNA鍜岄叾娲绘€х殑琛ㄨ揪鏉ヨ皟鑺備笌璋峰厜鑻疯偨鐩稿叧鐨勯叾锛岃€屼笉鍗曟槸閫氳繃璋冭妭GPx/GR閰剁殑娲绘€ф潵棰勯槻姘у寲鎹熶激銆侳aria绛塠16]閫氳繃鍘熻姳闈掔礌5绉嶄笉鍚岀粨鏋勬垚鍒?鍗曚綋锛岀洿鍒颁簲鑱氫綋)鍒嗗埆浣滅敤浜庝汉涔宠吅鐧岀粏鑳炴牚MCF-7鏉ヨ瘎浠疯繖浜涘寲鍚堢墿瀵圭粏鑳炴垚娲诲姏鍜屽娈栫殑褰卞搷锛岀粨鏋滄樉绀猴紝鍦?0mol/L鏃讹紝浜岃仛浣撳拰涓夎仛浣撹兘闄嶄綆缁嗚優鐨勬垚娲诲姏鍜屽娈栵紝鑰屽湪60mol/L鏃舵病鏈夎繖绉嶄綔鐢ㄣ€傚効鑼剁礌鍦?0鍜?0mol/L鏃堕兘鑳藉噺灏戠粏鑳炵殑鎴愭椿鍔涘拰澧炴畺銆傚疄楠岃繕鍙戠幇锛屽師鑺遍潚绱犵殑杩欎簺鎴愬垎鎵€琛ㄧ幇鐨勮緝楂樼殑鎶楁哀鍖栨椿鎬у缁嗚優鎴愭椿鍔涖€佸娈栨晥鏋滈兘鏄竴鏍风殑锛屽叾浣滅敤鏈哄埗杩橀渶杩涗竴姝ョ爺绌躲€?/font>
姘у寲鎹熶激鏄櫧鍐呴殰鍙戠敓涓渶鍏锋湁鎰忎箟鐨勭幆鑺傦紝璁稿瀹為獙閮借瘉鏄庢櫠鐘朵綋鐨勬哀鍖栨崯浼ゅ彂鐢熷湪鏅剁姸浣撴贩娴婁箣鍓嶃€傛姉姘у寲鍓傚缁寸敓绱燙銆佺淮鐢熺礌E鍜岃儭钀濆崪绱犺兘闃绘瀹為獙璇卞鐨勭櫧鍐呴殰鐨勫彂鐢熷凡鏈夎澶氭姤閬擄紝鐒惰€岋紝鍘熻姳闈掔礌瀵圭櫧鍐呴殰鐨勫舰鎴愮殑褰卞搷杩樺緢灏戞湁鐮旂┒銆俌amakoshi绛塠17]鐢ㄨ憽钀勭苯鎻愬彇鐗?鍚師鑺遍潚绱?8.5%)鍠傚吇閬椾紶鐧藉唴闅滃皬榧?ICR/f 榧?锛岄噰鍙栨爣鍑嗛ギ椋燂紝椋熺墿涓師鑺遍潚绱犵殑鍚噺鏄?鎴?.082%銆?7d鍚庤闅欑伅涓嬭瀵燂紝钁¤悇绫芥彁鍙栫墿鑳芥槑鏄鹃樆姝㈡垨鎺ㄨ繜鐧藉唴闅滅殑褰㈡垚锛屼笌瀵圭収缁勭浉姣旓紝鏅剁姸浣撶殑閲嶉噺鍜孧DA鍚噺鍙婅娴嗚儐鍥洪唶閰繃姘у寲姘?ChE-OOH)姘村钩鏄庢樉闄嶄綆銆傜粨鏋滆〃鏄庯紝鍘熻姳闈掔礌鍜屽叾鎶楁哀鍖栦唬璋骇鐗╃敱浜庡畠浠殑鎶楁哀鍖栨椿鎬ц兘棰勯槻鐧藉唴闅滅殑褰㈡垚銆?/font>
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4 Garcia-Ramirez B, Fernandez-Larrea J, Salvado MJ, Ardevol A, Arola L, Blade C. Tetramethylated dimeric procyanidins are detected in rat plasma and liver early after oral administration of synthetic oligomeric procyanidins. J Agric Food Chem ,2006;54(7):2543-2551
5 Shoji T, Masumoto S, Moriichi N, Akiyama H, Kanda T, Ohtake Y, Goda Y. Apple procyanidin oligomers absorption in rats after oral administration: analysis of procyanidins in plasma using the porter method and high-performance liquid chromatography/tandem mass spectrometry. J Agric Food Chem ,2006;54(3):884-892
7 Bagchi D, Garg A, Krohn RL, Bagchi M, Bagchi DJ, Balmoori J, Stohs SJ. Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. Gen Pharmacol ,1998;30(5):771-776
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