绗洓绔?/span>  姘у寲杩樺師骞宠　绯荤粺

鐩墠娴佽鐨勮鐐硅涓猴紝鏈轰綋瀛樺湪涓ょ被鎶楁哀鍖栫郴缁燂紝涓€绫绘槸閰舵姉姘у寲绯荤粺锛屽寘鎷秴姘у寲鐗╂鍖栭叾(SOD)銆佽繃姘у寲姘㈤叾(CAT)銆佽胺鑳辩敇鑲借繃姘у寲鐗╅叾(GSH-Px)绛夛紱鍙︿竴绫绘槸闈為叾鎶楁哀鍖栫郴缁燂紝鍖呮嫭缁寸敓绱?/span>C銆?/span>銆佽胺鑳辩敇鑲姐€佽お榛戠礌銆?/span>α-纭緵閰搞€佺被鑳¤悵鍗滅礌銆佸井閲忓厓绱犻摐銆侀攲銆佺(Se)绛夈€備袱涓郴缁熷苟涓嶆槸瀛ょ珛鐨勶紝鑰屾槸涓€涓暣浣擄紝閰舵姉姘у寲绯荤粺鐨勪綔鐢ㄦ槸鍌寲鎶楁哀鍖栧弽搴旓紝鑰岄潪閰舵姉姘у寲绯荤粺鏄姉姘у寲鍙嶅簲鐨勫簳鐗┿€?/span>

鐩墠鎶楁哀鍖栫殑瑙傜偣瀹為檯涓婃槸浠庢墍鏈夎嚜鐢卞熀鏈夋瘨鐨勫墠鎻愬嚭鍙戠殑锛屾棦鐒惰嚜鐢卞熀鏄噸瑕佺殑鐢熺墿娲绘€х墿璐紝缁х画绉版姉姘у寲绯荤粺瀹规槗璇锛屾湰浜鸿涓哄簲绉颁负姘у寲杩樺師骞宠　绯荤粺銆傝繖绫讳技浜庨吀纭峰钩琛＄郴缁燂紝涓轰簡缁存寔浣撳唴閰哥》骞宠　鐨勭ǔ瀹氾紝鏈轰綋閲囩敤鐨勬墜娈垫槸澶ч噺浣跨敤缂撳啿绯荤粺锛屽鏋滄病鏈夎繖浜涚紦鍐茬郴缁燂紝浣撳唴灏嗛潪甯稿鏄撳嚭鐜伴吀纭峰钩琛＄殑澶у箙搴︽尝鍔紝鐢氳嚦瀵艰嚧缁嗚優鍔熻兘鐨勪抚澶便€傛哀鍖栬繕鍘熶篃鏄竴绉嶅钩琛★紝鏈轰綋涔熸槸閲囩敤缂撳啿鐨勬柟娉曟潵缁存寔姘у寲杩樺師骞宠　鐨勩€?/span>

涓€銆佹満浣撴姉姘у寲鐨勬湰璐?/span>

鍓嶉潰鎴戜滑宸茬粡璁茶繃锛屾哀姘旀槸浣撳唴鍞竴鐨勭數瀛愭渶缁堟帴鍙椾綋锛屼篃鍙互鐞嗚В涓烘哀姘旀槸浣撳唴姘у寲鐨勫敮涓€鏈€缁堟潵婧愩€傛垜浠汉浣撴瘡澶╂秷鑰楃殑姘ф皵鏄灏戯紵涓嶅悓娲诲姩鐘舵€佺殑宸埆闈炲父澶э紝渚嬪鍦ㄧ潯鐪犳椂姣忓垎閽熻€楁哀閲忎负0.24 L锛岃€屽湪鍓х儓杩愬姩鏃舵瘡鍒嗛挓鑰楁哀閲忎负2.8 L銆傚洜姝わ紝浜轰綋姣忓ぉ娑堣€楃殑姘ф皵浠?/span>350 L鍜?/span>4000 L涓嶇瓑銆傜洰鍓嶈鐐硅涓猴紝浜轰綋娑堣€楃殑姘ф皵涓ぇ绾?/span>2%杞寲涓烘椿鎬ф哀锛屾寜鐓ц繖涓瘮渚嬭绠楋紝涓嶉毦寰楀嚭锛屾瘡澶╀汉浣撲骇鐢熸椿鎬ф哀鐨勬€婚噺鏄?/span>7 L鍜?/span>80 L姘ф皵銆傝繖鏄竴涓粈涔堢骇鍒殑鏁伴噺锛岃川閲忓ぇ姒傛湁10 g鍜?/span>114 g锛屾垨0.3鍜?/span>3.6鎽╁皵銆?/span>

棣栧厛鐪嬪叧浜庣淮鐢熺礌C鐨勬暟鎹紝姝ｅ父鎴愪汉浣撳唴鐨勭淮鐢熺礌C浠ｈ阿娲绘€ф睜涓害鏈?/span>1.5 g锛屾渶楂樺偍瀛樺嘲鍊间负3 g锛屾垨0.009鍜?/span>0.018鎽╁皵銆傚啀鐪嬪叧浜庣淮鐢熺礌E鐨勬暟鎹紝鎴愪汉鏈嶇敤鐩稿澶у墏閲忕殑缁寸敓绱?/span>E(鍙虫棆-α-鐢熻偛閰?/span>400-800 mg/d)缁忓勾绱湀鑰屾棤浠讳綍鏄庢樉鎹熷锛屾湇鐢?/span>800-3200 mg/d鑰咃紝鍋跺皵浼氬嚭鐜拌倢鑲夎“寮憋紝鐤插姵锛屽憰鍚愬拰鑵规郴锛屾湇鐢ㄧ淮鐢熺礌E瓒呰繃1000 mg/d鏃舵渶鏄庢樉鐨勬瘨鎬т綔鐢ㄦ槸瀵?/span>浣滅敤鐨勬嫯鎶楀苟澧炲己浜嗗彛鏈嶉璞嗙礌鎶楀嚌鍓傜殑浣滅敤锛屾鍙鑷存槑鏄剧殑鍑鸿銆傝澶氫汉璁や负锛岀淮鐢熺礌E鍜?/span>C锛屾垨鑰呭啀鍔?/span>A锛屾槸閲嶈鐨勫婧愭€ф姉姘у寲鍚岀洘锛岃ˉ鍏呰繖浜涚淮鐢熺礌鏄鎶楁哀鍖栨崯浼ょ殑鏈夋晥鎵嬫锛岃繖鏄澶氬鍚堢淮鐢熺礌浜у搧鍟嗗鏈€鍠滄鐨勮璇嶃€傞€氳繃涓婅堪璁＄畻鎴戜滑灏卞緢瀹规槗鍙戠幇锛屽嵆浣挎妸浣撳唴鎵€鏈夌殑缁寸敓绱犻兘鐢ㄤ笂锛堣繖鏄笉鍙兘鐨勶紝鍥犱负浼氬鑷翠弗閲嶇殑绱婁贡锛夛紝涔熸棤娉曞浣撳唴娲绘€ф哀鐨勬€婚噺浜х敓鑳芥劅瑙夊埌鐨勫共鎵帮紝鐢氳嚦涔熷彲浠ヨ娌℃湁褰卞搷銆?/span>

涔熻鏈夎繖鏍风殑鐤戦棶锛屼綋鍐呮湁鏇撮珮娴撳害鐨勫唴婧愭€ф姉姘у寲鐗╄川锛屼緥濡傝胺鑳辩敇鑲姐€傜洰鍓嶆祦琛岀殑瑙傜偣璁や负锛岃胺鑳辩敇鑲芥槸閲嶈鐨勫唴婧愭€ф姉姘у寲鐗╄川锛屽叾鏈€閲嶈浣滅敤鏄淮鎸佷綋鍐呭悇绉嶈泲鐧界殑宸熀澶勪笌杩樺師鐘舵€侊紝瀹為檯涓婂嵆浣挎妸浣撳唴鎵€鏈夌粏鑳炰腑铔嬬櫧鐨勫矾鍩洪兘璁＄畻鍦ㄥ唴锛岃繖鍖呮嫭鎵€鏈夌殑璋疯儽鐢樿偨锛屽叾娴撳害涔熷彧鏈?/span>5 mM浠ヤ笅锛屾寜鐓ф渶澶ф祿搴﹁绠楋紝鍏ㄨ韩鐨勫矾鍩哄惈閲忔渶澶氬彧鏈?/span>0.2鎽╁皵锛岃繖涔熷氨鏄洰鍓嶆墍鍏鐨勪綋鍐呮渶澶х殑鎶楁哀鍖栧偍澶囪兘鍔涖€?/span>

鎸夌収鐩墠鐨勬姉姘у寲瑙傜偣锛屾牴鎹互涓婃暟鎹紝鍙互杩欐牱璇达紝鍗充娇鍦ㄥ畨闈欑姸鎬侊紝浣撳唴鑷韩浜х敓鐨勬椿鎬ф哀鏍规湰鏃犳硶琚湁鏁堟竻闄ゃ€傚鏋滅湡鏄繖鏍风殑璇濓紝鎴戜滑澶ф閮戒笉鑳界敓瀛樹笅鍘汇€備簨瀹炰笂鎴戜滑閮芥病鏈夊彈鍒伴潪甯告樉钁楃殑姘у寲鎹熶激銆備负浠€涔堜粠鐜板湪鍏鐨勬哀鍖栨姉姘у寲鐞嗚浼氬緱鍑鸿繖鏍疯崚璋殑鎺ㄨ锛屽埌搴曚粈涔堝湴鏂瑰嚭鐜颁簡閿欒锛?/span>

杩欐秹鍙婂埌鏈珷鐨勪富瑕侀棶棰橈紝鎶楁哀鍖栫殑鏈川鏄粈涔堬紝鎴栬€呰浣撳唴鎶楁哀鍖栫殑婧愬ご鏄粈涔堛€傚墠闈㈡垜浠浘缁忔彁鍒帮紝鐪熸鎶楁哀鍖栫殑婧愬ご鏄垜浠憚鍙栨垨鍌ㄥ瓨鍦ㄤ綋鍐呯殑鑳介噺鐗╄川锛屽寘鎷硸銆佽剛鑲拰铔嬬櫧銆備笁缇ч吀寰幆鏄兘閲忎唬璋㈢殑閲嶈鏋㈢航锛岀粡杩囦笁缇ч吀寰幆锛岃兘閲忕墿璐ㄦ妸鐢靛瓙浼犻€掔粰閫掔數瀛愪綋锛岃繘鍏ユ哀鍖栫７閰稿寲浜х敓鍙緵缁嗚優鐩存帴浣跨敤鐨勮兘閲忕墿璐ㄣ€傚湪杩欎釜杩囩▼涓紝涓嶆柇浜х敓鐨勯€掔數瀛愪綋灏辨槸杩樺師浣滅敤鐨勬簮澶达紝鐢靛瓙鍦ㄦ哀鍖栫７閰稿寲杩囩▼浣?/span>89%鐨勬哀姘旇繕鍘燂紝鍙﹀2%鐨勬哀姘斿彉鎴愭椿鎬ф哀锛屽悓鏍锋槸琚繖浜涜兘閲忕墿璐ㄤ骇鐢熺殑鐢靛瓙鎵€杩樺師涓拰銆?/span>

閭ｄ箞鍏蜂綋杩囩▼鏄€庢牱鐨勶紵渚嬪褰撶粏鑳炲唴鐢熸垚灏戦噺杩囨哀鍖栨阿鏃讹紝GSH鍦ㄨ胺鑳辩敇鑲借繃姘у寲鐗╅叾甯姪涓嬶紝鍙妸杩囨哀鍖栨阿杩樺師鎴愭按锛屼絾鍏惰嚜韬琚哀鍖栦负GSSG銆傝繖閲岄渶瑕佺壒鍒敞鎰忕殑鏄紝灏界娲绘€ф哀琚腑鍜屼簡锛岀粏鑳炲唴鐨勬哀鍖栧紶鍔涘苟娌℃湁鍑忓皯锛屼笉杩囨槸鎶婃哀鍖栧紶鍔涗紶閫掔粰浜嗘哀鍖栧瀷璋疯儽鐢樿偨銆?/span>GSSG鐢卞瓨鍦ㄤ簬鑲濊剰鍜岀孩缁嗚優涓殑璋疯儽鐢樿偨杩樺師閰跺偓鍖栦綔鐢ㄤ笅锛屾帴鍙楁潵鑷?/span>NADPH鐢靛瓙杩樺師鎴?/span>GSH锛屼娇浣撳唴鑷敱鍩虹殑娓呴櫎鍙嶅簲鑳藉鎸佺画杩涜銆傝娉ㄦ剰锛岃繖閲屾彁渚涚數瀛愮殑NADPH锛屽畠浠殑鐢靛瓙鏄€庝箞鑾峰緱鐨勩€?/span>NADPH涓€鑸彨杩樺師鍨嬭緟閰垛叀锛屼篃鍙儫閰拌兒鑵哄槍鍛や簩鏍歌嫹閰哥７閰革紝鏉ヨ嚜浜庣淮鐢熺礌PP锛堜篃鏄竴绉嶇淮鐢熺礌锛夈€傚湪寰堝鐢熺墿浣撳唴鐨勫寲瀛﹀弽搴斾腑锛岀壒鍒槸鍦ㄨ剛鑲唬璋腑鍙戞尌閫掓阿浣撲綔鐢紝鍏锋湁閲嶈鎰忎箟銆傜７閰告垔绯栭€斿緞鏄憽钀勭硸姘у寲鍒嗚В鐨勪竴绉嶆柟寮忥紝涔熸槸缁嗚優灏?/span>NADP⁺杞寲鎴?/span>NADPH鐨勯噸瑕佹柟寮忥紝鎵€浠ワ紝NADPH鐨勭數瀛愭垨姘㈠師瀛愪富瑕佹潵鑷憽钀勭硸姘у寲鍒嗚В銆備篃灏辨槸璇达紝缁嗚優瑕佺淮鎸佽胺鑳辩敇鑲藉鍦ㄦ哀鍖栫姸鎬侀渶瑕佹寔缁笉鏂湴浠庤兘閲忕墿璐ㄦ哀鍖栧垎瑙ｈ幏寰楄繕鍘熸€у姩鍔涳紝杩欏氨鏄綋鍐呮姉姘у寲鐨勬湰璐ㄣ€?/span>

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