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銆€銆€鍚屾椂锛屽敖绠T姣掔礌铔嬬櫧涓€鐩磋璁や负鏄壒寮傛€х殑鏉€铏泲鐧斤紝瀵逛汉鍙婂叾瀹冭剨妞庡姩鐗╂棤瀹筹紝浣嗘槸鐮旂┒琛ㄦ槑锛岄€氳繃鍩哄洜鏀归€狅紝涓嶄粎鍙互鏀瑰彉BT姣掔礌铔嬬櫧鐨勯澏鐢熺墿鍜岄澏缁嗚優鑼冨洿锛岃€屼笖鍙互澶у箙搴︽彁楂楤T姣掔礌铔嬬櫧鍦ㄦ鐗╂€昏泲鐧戒腑鐨勫惈閲忋€傚绉嶅父瑙佺殑缁嗚弻姣掔礌濡傚ぇ鑲犳潌鑿岀礌A(ColicinA) 銆佺櫧鍠夋瘨绱?Diphtheria)绛夊拰BT姣掔礌铔嬬櫧鐨勪竴绾х粨鏋勫拰浣滅敤鏈哄埗铏界劧涓嶅悓, 浣嗗畠浠兘鍏峰叡鍚岀殑涓夌淮鏋勮薄鐗瑰緛锛屽苟涓斿鍓嶆墍杩帮紝鍦ㄦ病鏈夌壒寮傛€у彈浣撴椂锛孊T铔嬬櫧涔熻〃鐜板嚭涓€瀹氱殑閫犳垚鐢熺墿鑶滅┛瀛旂殑鐜拌薄銆傚悓鏃讹紝Perlak 绛夊厛鍚庨€氳繃鍩哄洜淇グ鍜屾敼閫狅紝鍒嗗埆鍦ㄦ鑺卞拰椹搩钖瓑浣滅墿涓紝灏咮T铔嬬櫧琛ㄨ揪鐨勬按骞虫彁楂樹簡鏁扮櫨鍊嶏紝鏈€楂樿揪鍒版鐗╂€昏泲鐧界殑0.3%[26-28]銆傚苟涓旓紝鎴戜滑鍦ㄦ敞鎰忔槅铏杞珺T鍩哄洜浣滅墿浜х敓鎶楄嵂鎬х殑鍚屾椂锛屼篃瑕佺湅鍒版姉鑽槅铏杞珺T鍩哄洜浣滅墿鐨勯€夋嫨鍙互瀵艰嚧妞嶇墿琛ㄨ揪鏇村BT铔嬬櫧鐨勫彲鑳芥€с€備汉宸ュ共棰勫拰鑷劧閫夋嫨鍧囧彲浠ュ杞珺T鍩哄洜鐨勬鐗╅€犳垚鍘嬪姏锛屼粠鑰屾墿灞曞叾鐗瑰紓鎬х殑闈剁粏鑳炶寖鍥存垨鎻愰珮鍏惰〃杈剧殑BT铔嬬櫧姘村钩锛屼粠鑰屽浜轰綋閫犳垚娼滃湪鐨勫厤鐤郴缁熷強鍏跺姛鑳界殑鎹熶激銆備緥濡傦紝涓€涓効绔ユ瘡澶╃殑铔嬬櫧鎽勫叆閲忓簲杈惧埌2.5g/kg锛堝┐骞煎効鏇村锛夛紝濡傛灉鍏朵腑鐨?0%鏉ヨ嚜杞珺T鍩哄洜妞嶇墿鐨勮泲鐧斤紙鎸夋€昏泲鐧界殑0.3%璁＄畻锛夛紝姣忓ぉ鐨凚T铔嬬櫧鎽勫叆閲忓皢杈惧埌3.75mg/kg銆傚鍓嶆墍杩帮紝璇T铔嬬櫧鐨勬憚鍏ラ噺宸茬粡鍗佸垎鎺ヨ繎鍙互寮曡捣鍏嶇柅绯荤粺鍙戣偛鍜屽姛鑳介殰纰嶇殑姘村钩锛屽苟鍙互閫氳繃鎶戝埗鐧界粏鑳炵敓鎴愶紝閫犳垚杩涗竴姝ョ殑鍏嶇柅绯荤粺鍔熻兘鎹熶激銆?br />銆€銆€鐮旂┒杩樺彂鐜帮紝灏界娌℃湁鑷寸暩鍜岃嚧绐佸彉鐨勭幇璞★紝楂樺墏閲忕殑BT铔嬬櫧瀵逛粩榧犵殑楠ㄩ楠ㄥ寲鏈変竴瀹氱殑寤剁紦浣滅敤[23]銆?br />銆€銆€鐢辨鍙锛孊T 姣掔礌铔嬬櫧瀵规満浣撶殑鍏嶇柅绯荤粺鍙婃満浣撶殑鍏嶇柅搴旂瓟瀛樺湪鐫€娼滃湪鐨勫▉鑳侊紝鑰屼笉浠呮槸鎴戜滑鍘熸潵棰勮鐨勮秴鏁忓弽搴斻€傛墍浠ワ紝閽堝BT 姣掔礌铔嬬櫧鐨勬綔鍦ㄥ▉鑳侊紝鎴戜滑蹇呴』閲囧彇鐩稿簲鐨勫簲瀵圭瓥鐣ャ€傞鍏堬紝BT 姣掔礌铔嬬櫧鏃犺€愮儹鎬? 鍦?5鈩冭秴杩?h 鎴?0鈩冭秴杩?0min , 灏辫兘澶卞幓娲绘€э紝涓斾笉婧朵簬姘存垨鏈夋満婧跺墏濡傛隘闃层€佷笝閰€佷箼閱氱瓑, 浠呮憾浜庣⒈鎬ф憾娑诧紝缁忎笁姘唻閰搞€佹隘鍖栦簹姹炵瓑澶勭悊寮曡捣铔嬬櫧璐ㄥ彉鎬ц€屽け鍘绘椿鎬э紝鍦ㄩ吀鎬ф垨涓€х幆澧冧腑瀹规槗闄嶈В锛屽洜姝や娇鐢˙T 铔嬬櫧涓轰富鐨勭敓鐗╁啘鑽槸瀹夊叏鐨勶紝鍏跺湪鍦熷￥涓殑娈嬬暀浠呬负3ng锛屼笉浼氬浜虹被鐨勫仴搴烽€犳垚鐩存帴鐨勫▉鑳併€備絾鏄紝鐢变簬杞珺T 鍩哄洜浣滅墿涓殑BT 铔嬬櫧涓嶆槗鍘婚櫎锛屽繀椤荤粡杩囧姞宸ュ鐞嗭紙濡傚姞鐑拰杩涜閰稿鐞嗭級锛屼娇鍏跺け娲绘墠鑳戒繚璇佸畨鍏紱鍏舵锛孊T 姣掔礌铔嬬櫧瀵逛簬鐗规畩浜虹兢锛屽闇€瑕佽泲鐧介噺澶т笖姝ｅ湪楠ㄩ鍙?br />銆€銆€鑲茬殑鍎跨鍙婅儍閰稿垎娉屼笉瓒崇殑浜虹兢锛屽彲鑳介€犳垚鍏嶇柅绯荤粺鍙戣偛鍙婂姛鑳戒弗閲嶉殰纰嶏紝鎵€浠ュ簲閬垮厤鍚戣繖浜涗汉缇ゆ彁渚涘惈BT 姣掔礌铔嬬櫧椋熺墿锛岀敱浜庤浆BT 铔嬬櫧鍩哄洜浣滅墿鐨勯仐浼犵墿璐ㄥ彲鑳芥薄鏌撳叾瀹冧綔鐗╋紝鍥犳蹇呴』涓ユ牸闄愬埗鍜屾帶鍒惰浆BT 鍩哄洜浣滅墿鐨勭妞嶏紱鏈€鍚庯紝灏界鐩墠杩樻病鏈夎浆BT 鍩哄洜椋熺墿閫犳垚鎬ユ€ц秴鏁忓弽搴旂殑涓村簥鎶ラ亾锛屼絾鏄姞宸ヨ浆鍩哄洜绋荤背鐨勫伐浜哄彲浠ュ鍏朵骇鐢烮gE 鍨嬫姉浣擄紝涓斿湪璞氶紶璇曢獙涓紝鍙鐨偆鍒烘縺鐥囩姸銆傝繖浜涢兘鎻愮ずBT 姣掔礌铔嬬櫧鍙兘寮曡捣瓒呮晱鍙嶅簲锛屽洜姝ゅ湪浣跨敤杞珺T 鍩哄洜鐢熺墿鏉ユ簮鐨勫埗鍝侊紙濡傝浆BT 鍩哄洜妫夎姳鐨勮。鐗╋級鏃讹紝瑕佽€冭檻寮曡捣瓒呮晱鍙嶅簲鐨勫彲鑳斤紝鏇剧粡鏈夎秴鏁忓弽搴旂梾鍙茬殑浜虹兢搴旇閬垮厤鎺ヨЕ锛屾墍浠ュ浜庤繖绫讳骇鍝佷篃搴旇杩涜鏍囪瘑绠＄悊銆?br />銆€銆€鎬讳箣锛岃浆BT鍩哄洜鏉€铏綔鐗╃殑鍑虹幇鍙兘瀵规満浣撶殑鍏嶇柅绯荤粺閫犳垚娼滃湪鐨勫奖鍝嶏紝鐢变簬杞熀鍥犺泲鐧藉彲鑳藉湪椋熺墿涓崰鏈夊緢澶у惈閲忥紝浜轰滑鍦ㄨ璇嗚繖绉嶅奖鍝嶆椂锛屽簲璇ヨ蛋鍑轰粎鍏冲績瓒呮晱鍙嶅簲鐨勮鍖猴紝鑰屾洿瑕佸叧娉ㄥ叾瀵瑰厤鐤郴缁熺殑鏁翠綋褰卞搷銆傝€屼笖锛岀敱浜庨€氬父璁や负鏁忔劅鐨勭敓鑲茬箒娈栨寚鏍囧湪寰敓鐗╁啘鑽垨杞熀鍥犳姉铏綔鐗╃殑妫€娴嬩腑锛岃繙杩滄病鏈夊厤鐤寚鏍囨晱鎰熷拰鏄撲簬瀹氶噺锛屽洜姝わ紝鏈変笓瀹舵棭灏卞懠鍚佸璁炬湁鍏崇殑鍏嶇柅鐩戞帶鎸囨爣杩涜璇曢獙鍜屽畨鍏ㄦ€ц瘎浠穂23]銆備粠鐩墠鎯呭喌鏉ョ湅锛屽湪鏈兘纭畾杞珺T鍩哄洜椋熷搧瀹夊叏鐨勭姸鎬佷笅锛岃繕鏄簲璇ヤ互浣跨敤鍜岀爺鍙態T铔嬬櫧绫荤殑鍐滆嵂涓轰富瑕佹柟鍚戯紝鑰屼笉搴斿湪杞熀鍥犵殑闂涓婅繃浜庡啋杩涖€?br />銆€銆€鍙傝€冩枃鐚?br />銆€銆€[1]. McConnell E, Richards AG. The Production by Bacillus thuringiensis Berliner of a heat stablesubstance toxic for insects. Can Microbil, 1959, 5: 161—168.
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銆€銆€Abstract In order to prevent plants from insects, food with transgenic insecticidal crystalproteins of Bacillus thuringiensis come into human daily life. The BT transgenic plants may killinsects by BT toxins. Some reports showed that BT proteins could not only induce IgE and IgGproduction and T cell mediated immune responses in vivo, which may potentially evoke allergy,but also could cause dysfunction of immune system. This dysfunction of immune system may bemore obviously in certain populations, such as children and babies. Thus, the potential effects ofBT transgenic food on immune system rather than its potential allergenicity should be considered,when the safety of BT transgenic food is being evaluated.
銆€銆€Keywords锛歵ransgenic corps, immunity, Allergy, Bacillus thuringiensis
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