鍦ㄦ渶杩戝弬鍔犵殑涓€娆″尰瀛︾鎶€鏌ユ柊鎶ュ憡澶嶅涓紝鎴戜滑鍙戠幇鏈夊緢澶氬尰瀛︽煡鏂版姤鍛婄殑鏁版嵁搴撴病鏈夋煡鍏紝鍙煡浜嗕竴閮ㄥ垎鏁版嵁搴擄紝杩欐槸寰堜笉鍙潬鐨勶紝涓嶈兘鏀惧績鐨勶紝绉戞妧鏌ユ柊蹇呴』鍦ㄦ煡鍏ㄩ兘鍩虹涓婃煡鍑嗐€?/font>
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涓€銆佹煡鏂板挩璇㈣鐐癸細锛堜富瑕佺爺绌跺唴瀹广€佹妧鏈柟娉曘€佹妧鏈寚鏍囥€佸垱鏂扮偣锛?/span>
璇ヨ棰樿繘琛屾娑?56鍙f湇娑叉姉鑲跨槫浣滅敤鐨勪复搴婂墠鐮旂┒銆傛娑?56鍙f湇娑?/span>缁勬垚鍖呮嫭鎮挬瀛愶紙鑼呰帗锛夈€佽棨姊ㄦ牴銆侀粍鑺€佺孩鏋g瓑锛屽悰鑽负鎮挬瀛愶紝鑷h嵂涓鸿棨姊ㄦ牴绛夛紝浣愯嵂涓洪粍鑺€備笂杩扮粍鏂归噰鐢ㄦ按鎻愭硶鍒跺鍙f湇娑诧紝骞跺鍚涜嵂杩涜鑼呰帗涓夎悳鎬荤殏鑻锋彁鍙栵紝搴旂敤MTT娉曞浜鸿〃鐨檶缁嗚優銆?span lang="EN-US">HR8348缁撹偁鐧岀粏鑳炪€佸皬榧?span lang="EN-US">B16榛戣壊绱犵粏鑳炵槫缁嗚優鍜?span lang="EN-US">S180
鑲夌槫缁嗚優杩涜浣撳鎶戠槫璇曢獙锛涘苟鍒嗗埆瀵瑰皬榧?span lang="EN-US">CT缁撹偁鐧岀Щ妞嶇槫銆佸皬榧犻粦鑹茬礌鐦ょЩ妞嶈偪鐦ゅ拰S180绉绘鑲夌槫杩涜浣撳唴鎶戠槫璇曢獙銆傝瘯楠岀粨鏉熷彇鐦ゅ簲鐢ㄥ厤鐤粍鍖栨硶娴嬪畾鍑嬩骸鍥犲瓙琛ㄨ揪鎯呭喌浠ョ‘瀹氳偪鐦ゅ噵浜℃儏鍐点€?span lang="EN-US">
鐮旂┒缁撴灉涓猴細鍦ㄤ綋澶栵紝楂樻祿搴︼紙1mg%锛夊拰涓祿搴︼紙0.1mg%锛夌殑鑼呰帗涓夎悳鎬荤殏鑻峰缁撹偁鐧?span lang="EN-US">HR8348缁嗚優鏍湁鏄庢樉鎶戞潃浣滅敤锛岃〃鐜颁负缁撹偁鐧岀粏鑳炲娈栨寚鏁版槑鏄句笅闄?span lang="EN-US">;楂樹腑浣庢祿搴﹁寘鑾撴€荤殏鑻峰浜鸿〃鐨檶缁嗚優鏃犳姂鏉€浣滅敤銆傚湪浣撳唴锛屾娑?/span>356鍙f湇娑插灏忛紶B16榛戣壊绱犵槫缁嗚優鍜岀粨鑲犵檶缁嗚優鏈夋姂鍒朵綔鐢紙鎶戠槫鐜囧垎鍒负61.84%鍜?span lang="EN-US">47.26%锛夛紱鑼呰帗涓夎悳鎬荤殏鑻峰缁撹偁鐧岀粏鑳炲拰灏忛紶B16榛戣壊绱犵槫缁嗚優鏈夋姂鍒朵綔鐢紝涓庡墏閲忓憟姝g浉鍏炽€傛娑?/span>356鍙f湇娑插灏忛紶B16榛戣壊绱犵槫缁嗚優鍜岀粨鑲犵檶缁嗚優鏈変績鍑嬩骸浣滅敤锛屼腑娴撳害鑼呰帗涓夎悳鎬荤殏鑻峰S180鑲夌槫鏈変績鍑嬩骸浣滅敤銆?/span>
浜屻€佹煡鏂板挩璇㈣姹傦細
1銆佹煡鏄庝笌璇ョ爺绌堕」鐩浉鍚屾垨绫讳技鐨勫浗鍐呭鐮旂┒鎶ラ亾锛?o:p>
2銆佸皢璇ョ爺绌跺唴瀹逛笌鍥藉唴澶栫爺绌惰繘琛屽姣斿垎鏋愶紱
3銆佸璇ョ爺绌堕」鐩殑鏂伴鎬т綔鍑哄垎鏋愯瘎浠枫€?o:p>
涓夈€佹绱㈡儏鍐碉細
1銆佹绱㈣寖鍥达細鍥藉唴澶?o:p>
2銆佹绱㈠伐鍏凤細
锛?锛夊浗澶栨枃鐚绱㈠伐鍏凤細
鈻?span lang="EN-US">INTERNET-PUBMED锛?span lang="EN-US">MEDLINE
缇庡浗鍖诲鏂囩尞鍏夌洏妫€绱㈢郴缁?/span>(MEDLINE-CDROM)
锛?span lang="EN-US">2锛?/span>鍥藉唴鏂囩尞妫€绱㈠伐鍏?/span>锛?span lang="EN-US">
鈻?/span>涓浗鐢熺墿鍖诲鏂囩尞鍏夌洏妫€绱㈢郴缁?/span>(CBM-disc)
鈻燙HKD璺ㄥ簱妫€绱㈠钩鍙帮紙鏈熷垔鍏ㄦ枃搴撱€佸崥纭曡鏂囧叏鏂囧簱銆佷細璁叏鏂囧簱锛?o:p>
鈻犲浗瀹剁鎶€鎴愭灉搴?o:p>
鈻犲浗瀹剁鎶€鍥句功鏂囩尞涓績锛圢STL锛?o:p>
锛?锛夌敓鐗╁尰瀛﹀弬鑰冧功銆佸伐鍏蜂功锛?o:p>
锛?锛夌幇鍒婏細
3銆佹绱㈡墜娈碉細 缃戠粶妫€绱?span style="mso-spacerun: yes"> 鍏夌洏妫€绱?span style="mso-spacerun: yes"> 鎵嬪伐妫€绱?o:p>
4銆佹绱㈤€斿緞锛?涓婚閫斿緞 銆€鑷敱璇嶉€斿緞
5銆佹绱㈢敤璇嶏細
鈶?/span>鎮挬瀛?span lang="EN-US"> or 鑼呰帗锛?span lang="EN-US">rubus parvifolius)
鈶?/span>鎬荤殏鑻?/span>(total saponins)
鈶㈣偪鐦?span lang="EN-US">[鎵╁睍鍏ㄩ儴鏍?span lang="EN-US">]/ 鍏ㄩ儴鍓富棰樿瘝 or 鑲跨槫(Neoplasms or carcinoma)
鈶?/span>琛ㄧ毊鐧?/span>(epidermal carcinoma) or 缁撹偁鑲跨槫[鎵╁睍鍏ㄩ儴鏍?span lang="EN-US">]/ 鍏ㄩ儴鍓富棰樿瘝锛?span lang="EN-US">Colonic Neoplasms锛?span lang="EN-US">or 缁撹偁鐧?span lang="EN-US"> or 榛戣壊绱犵槫[鎵╁睍鍏ㄩ儴鏍?span lang="EN-US">]/ 鍏ㄩ儴鍓富棰樿瘝(Melanoma) or 榛戣壊绱犵槫 or 鑲夌槫[鎵╁睍鍏ㄩ儴鏍?span lang="EN-US">]/ 鍏ㄩ儴鍓富棰樿瘝(Sarcoma) or 鑲夌槫
6銆佹绱㈢瓥鐣?/span>锛?span lang="EN-US">
#1 鈶?span lang="EN-US"> and 鈶?span lang="EN-US" style="mso-bidi-font-weight: bold">
#2 鈶?span lang="EN-US"> and 鈶?span lang="EN-US"> and 鈶?span lang="EN-US" style="mso-bidi-font-weight: bold">
#3 鈶?span lang="EN-US"> and 鈶?span lang="EN-US">
鍥涖€佹绱㈢粨鏋?/span>锛?/span>
1銆佹绱㈢粨鏋滄€昏〃
2銆佸悇妫€绱㈠伐鍏锋绱㈡儏鍐典竴瑙堣〃锛?o:p>
妫€绱㈠伐鍏?/span>
|
妫€绱㈠勾闄愶紙璧锋骞达級
|
妫€绱㈡枃鐚€婚噺
|
妫€鍑烘枃鐚噺
|
瀵嗗垏鐩稿叧鏂囩尞
|
CBM-disc
|
1978.1-2008
|
518涓囦綑
|
8
|
3
|
CHKD璺ㄥ簱妫€绱㈠钩鍙?o:p>
|
1994-2008
|
600涓囦綑
|
17
|
3
|
鍥藉绉戞妧鎴愭灉搴?o:p>
|
1978-2008
|
17涓囦綑
|
0
|
0
|
鍥藉绉戞妧鍥句功鏂囩尞涓績
|
1981-2008
|
2300涓囦綑
|
6
|
0
|
MEDLINE-PUBMED
|
1966-2008
|
1700涓囦綑
|
8
|
0
|
3銆佺浉鍏虫枃鐚?o:p>
1銆侀儜鎸川(1); 寮犵幉鑿?2); 榛勫阀鐜?1); 榛勫父鏂?1); 灏夋檽鍐?1); 搴斿崕蹇?3); 鍙跺缓鏍?1)锛?1)鏉窞甯傜涓変汉姘戝尰闄?鏉窞310009; (2)娴欐睙澶у鍖诲闄㈤檮灞炵涓€鍖婚櫌,鏉窞310003; (3)娴欐睙涓尰鑽ぇ瀛﹀姩鐗╁疄楠屼腑蹇?鏉窞 310053锛? 鑼呰帗鎬荤殏鑻峰涓夌鐨偆鑲跨槫鐨勪綋澶栨姉鑲跨槫浣滅敤. 涓浗涓タ鍖荤粨鍚堢毊鑲ゆ€х梾瀛︽潅蹇?span style="mso-spacerun: yes"> 2007; 6(2): 67-69
鐩殑:璇勪环鑼呰帗鎬荤殏鑻峰涓夌鐨偆鑲跨槫鐨勪綋澶栨姉鑲跨槫鑽晥浣滅敤銆傛柟娉?鐢ˋ375榛戣壊绱犵槫缁嗚優銆丠ut-78浜虹毊鑲缁嗚優娣嬪反鐦ょ粏鑳炲拰A431浜鸿〃鐨檶缁嗚優涓虹檶缁嗚優鏍?瑙傚療鑼呰帗鎬荤殏鑻风殑浣撳鎶楄偪鐦や綔鐢ㄣ€傜粨鏋?鑼呰帗鎬荤殏鑻峰A375榛戣壊绱犵槫缁嗚優鍜孒ut-78浜虹毊鑲缁嗚優娣嬪反鐦や袱绉嶇毊鑲よ偪鐦ょ粏鑳炵殑澧炴畺鏈夋槑鏄剧殑鎶戝埗浣滅敤,涓庡鐓х粍姣旇緝宸紓鏈夋樉钁楁€?P<0.05);瀵逛汉琛ㄧ毊鑲ょ檶缁嗚優鏃犳槑鏄炬姂鍒朵綔鐢ㄣ€傜粨璁?鑼呰帗鎬荤殏鑻峰A375榛戣壊绱犵槫缁嗚優鍜孒ut-78浜虹毊鑲缁嗚優娣嬪反鐦や袱绉嶇毊鑲よ偪鐦ょ粏鑳炴湁鏄庢樉鐨勬姉鑲跨槫娲绘€с€?o:p>
2銆侀儜鎸川(1); 榛勫父鏂?1); 榛勫阀鐜?1); 灏夋檽鍐?1); 鍚存睈鎬?2); 鍛ㄥ崼姘?3)锛?1)鏉窞甯傜涓変汉姘戝尰闄㈠绉?310009; (2)娴欐睙楂樼瓑鍖诲涓撶瀛︽牎; (3)娴欐睙涓尰鑽ぇ瀛︼級. 鑼呰帗鎬荤殏鑻锋姉鑲跨槫浣滅敤鍙婅瀵艰偪鐦ょ粏鑳炲噵浜$殑鐮旂┒. 涓崕瀹為獙澶栫鏉傚織 2007; 24(5): 639
鏈爺绌舵棬鍦ㄨ瀵熻寘鑾撴€荤殏鑻风殑浣撳唴澶栨姉鑲跨槫娲绘€у強瀵归粦鑹茬礌鐦ゅ拰S180鑲夌槫缁嗚優鍑嬩骸鐨勫奖鍝嶃€?o:p>
3銆侀儜鎸川(1); 寮犵幉鑿?2); 榛勫父鏂?2); 榛勫阀鐜?2); 灏夋檽鍐?2); 鍙跺缓鏍?2)锛?1)鏉窞甯傜涓変汉姘戝尰闄?310009; (2)娴欐睙澶у鍖诲闄㈤檮灞炵涓€鍖婚櫌, 310006锛? 鑼呰帗鎬荤殏鑻蜂綋澶栨姉鑲跨槫浣滅敤鐮旂┒. 娴欐睙涓村簥鍖诲 2007; 9(5): 611-612
鑼呰帗(Rubus parviflolius L.),鍒悕澶╅潚鍦扮櫧鑽夈€佺孩姊呮秷銆佷笁鏈堟场,涓鸿敺钖囩鎮挬瀛愭鐗?鍏锋湁娲昏鍖栫榾,娓呯儹瑙f瘨绛変綔鐢ㄣ€傛湰鐮旂┒閫夋嫨浜咹R8348鐩磋偁鑵虹檶缁嗚優銆丄375榛戣壊绱犵槫缁嗚優銆丠ut-78浜虹毊鑲缁嗚優娣嬪反鐦ょ粏鑳炲拰A431浜鸿〃鐨檶缁嗚優涓虹檶缁嗚優鏍?鐢ㄨ寘鑾撴€荤殏鑻峰瀹冧滑杩涜浣撳鎶楄偪鐦よ瘯楠?鍚屾椂妫€娴嬩簡鑼呰帗鎬荤殏鑻峰HR8348鐩磋偁鑵虹檶鍛ㄦ湡鐨勫奖鍝?缁撴灉鏄剧ず瀵瑰墠涓夌鑲跨槫鏈夎壇濂界殑鎶楄偪鐦ゆ椿鎬?閫氳繃灏嗙粏鑳炲懆鏈熼樆婊炲湪S鏈熷湪鑰屽彂鎸ユ姉鑲跨槫浣滅敤銆?o:p>
4銆侀儜鎸川; 寮犵幉鑿? 榛勫父鏂? 榛勫阀鐜? 灏夋檽鍐? 鍚存睈鎬? 鍛ㄥ崼姘?鏉窞甯傜涓変汉姘戝尰闄? 娴欐睙澶у鍖诲闄㈤檮灞炵涓€鍖婚櫌; 娴欐睙涓尰鑽ぇ瀛﹀姩鐗╁疄楠屼腑蹇? 娴欐睙鏉窞). 鑼呰帗鎬荤殏鑻峰榛戣壊绱犵槫鐨勬姉鑲跨槫浣滅敤鐮旂┒.涓浗涓嵂鏉傚織 2007锛?2(19):2055-2058
鐩殑:璇勪环鑼呰帗鎬荤殏鑻峰榛戣壊绱犵槫鐨勪綋鍐呫€佸鎶楄偪鐦よ嵂鏁堜綔鐢ㄣ€傛柟娉?A375浜烘伓鎬ч粦鑹茬礌鐦ょ粏鑳炰綋澶栧父瑙勪紶浠e煿鍏?闅忔満鍒?缁?鍒嗗埆鍔犲叆鐜7閰拌兒,鑼呰帗鎬荤殏鑻烽珮銆佷腑銆佷綆(0.01, 0.001, 0.000 1 mg·mL-1)3涓川閲忔祿搴?浠ヤ笉鍔犺嵂浣滈槾鎬у鐓?MTT娉曟娴嬭寘鑾撴€荤殏鑻风殑浣撳鎶楄偪鐦や綔鐢?鐢˙16榛戣壊绱犵槫缁嗚優绉绘灏忛紶,闅忔満鍒嗛槼鎬ц嵂(鐜7閰拌兒)缁?鑼呰帗鎬荤殏鑻烽珮銆佷腑銆佷綆(100, 50, 25 mg·kg-1)鍓傞噺缁勫強闃存€ц嵂(鐢熺悊鐩愭按)缁?瑙傚療浣撳唴鎶戠槫鏁堟灉銆佽嵎鐦ゅ皬榧犵敓瀛樻椂闂村拰鐢熷懡寤堕暱鐜?鍚屾椂閲囩敤TUNEL娉曟娴嬭寘鑾撴€荤殏鑻峰B16榛戣壊绱犵槫缁嗚優鍑嬩骸鐨勫奖鍝嶃€傜粨鏋?浣撳鎶戠槫璇曢獙鏄剧ず,楂樸€佷腑璐ㄩ噺娴撳害鑼呰帗鎬荤殏鑻风粍涓庨槾鎬у鐓х粍姣旇緝,P<0.05,鏈夌粺璁″鎰忎箟;浣撳唴鎶戠槫璇曢獙鏄剧ず,楂樺墏閲忕粍骞冲潎鐦や綋绉槑鏄句綆浜庨槾鎬у鐓х粍(P<0.05),鎶戠槫鐜?7.02%;鑽稡16榛戣壊绱犵槫灏忛紶鐢ㄨ寘鑾撴€荤殏鑻锋不鐤楀悗瀛樻椿鏃堕棿澧炲姞;鑼呰帗鎬荤殏鑻烽珮銆佷腑銆佷綆鍓傞噺缁勯粦鑹茬礌鐦ょ粏鑳炲噵浜℃寚鏁板垎鍒负32.5%, 20.5%鍜?.5%,涓庨槾鎬у鐓х粍(3.5% )姣旇緝宸紓鏈夌粺璁″鎰忎箟銆傜粨璁?鑼呰帗鎬荤殏鑻峰浣撳唴銆佸榛戣壊绱犵槫缁嗚優鏈夋姂鍒朵綔鐢?骞跺憟閲忔晥渚濊禆鍏崇郴,鑳介€氳繃淇冭繘榛戣壊绱犵槫缁嗚優鍑嬩骸鑰屽彂鎸ユ姉鑲跨槫娲绘€с€?o:p>
5銆佺帇鎸崕; 鏉庡繉; 閮戣崳姊? 鐜嬫枌璐? 璐惧繝寤猴紙鍏板窞澶у鐢熺墿绯?730000锛? 鑿板附鎮挬瀛愪笁钀滅硸閰殑浣撳鎶楄偪鐦ゆ椿鎬? 涓浗鑽鏉傚織 1999.03.08; 34(3): 163-164
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6銆?/span>Kim EJ, Lee YJ, Shin HK, Park JH. Induction of apoptosis by the aqueous extract of Rubus coreanum in HT-29 human colon cancer cells. Nutrition. 2005 Nov-Dec;21(11-12):1141-8.
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3銆佸浗鍐呭鏈夋枃鐚爺绌舵偓閽╁瓙鎻愬彇鐗╀綋澶栨姉鑲跨槫浣滅敤銆傚浗鍐呭叞宸炲ぇ瀛︾帇鎸崕绛夌爺绌朵粠浼犵粺涓嵂鑿板附鎮挬瀛?/span>涓彁鍙栫殑3绉嶄笁钀滅硸閰浜鸿倽鐧岀粏鑳濨EL-7402銆佷汉鐧借鐥呯粏鑳濳562銆佸皬榧犻粦鑹茬礌鐦16鐨勪綋澶栨姉鑲跨槫娲绘€э紙瑙佹枃鐚?锛夛紱鍥藉Kim EJ绛夋帰璁ㄦ偓閽╁瓙姘存彁鍙栫墿鍦ㄤ汉缁撹偁鐧岀粏鑳?span lang="EN-US">HT-29涓殑璇卞鍑嬩骸浣滅敤锛堣鏂囩尞6锛夛紱浣嗘墍鏌ユ枃鐚湭鍚屾椂鐮旂┒鑼呰帗鎬荤殏鑻峰榛戣壊绱犵槫銆佽〃鐨檶銆佽倝鐦ゃ€佺洿鑲犺吅鐧岀殑浣撳唴澶栨姉鑲跨槫浣滅敤銆?/span>