| [2] 鏍囬锛?/td>
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| 鍙戣〃璇勮浜猴細 |
Biological Effects of Electrolyzed Water in Hemodialysis
Masaaki Nakayamaa, Shigeru Kabayamac, Hirofumi Nakanod, Wan-Jun Zhua, c, Hiroyuki Terawakia, Keisuke Nakayamaa, Kiyoshi Katohb, Toshinobu Satohb, Sadayoshi Itoa, b
aResearch Division of Dialysis and Chronic Kidney Disease, Tohoku University Graduate School of Medicine,
bDepartment of Blood Purification, Tohoku University Hospital, Sendai,
cNihon Trim Co. Ltd., Osaka,
dDialysis Center, Kashima Hospital, Iwaki, Japan
Address of Corresponding Author
Nephron Clin Pract 2009;112:c9-c15 (DOI: 10.1159/000210569)
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Key Words
Hemodialysis
Electrolyzed water
Oxidative stress
Methylglyoxal
Neutrophils
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Abstract
Background/Aims: The application of electrolyzed water (EW) at the cathode side to manufacture reverse osmosis (RO) water and hemodialysis (HD) solution can actually lead to less oxidative capacity in chemical terms. The present study examined the biological actions of this water on human polymorphonuclear leukocytes (PMNs), and the clinical feasibility of applying this technology to HD treatment. Methods: RO water using EW (e-RO) exhibited less chemiluminescence in luminol-hydrogen peroxide and higher dissolved hydrogen levels (-99.0 ppb) compared with control RO water. The effects of e-RO on PMN viability were tested. HD using e-RO was performed for 12 consecutive sessions in 8 patients for the feasibility test. Results: Basal cellular viability and function to generate superoxide radicals of PMNs were better preserved by e-RO application. In the clinical trial, reductions of blood pressure were noted, but no adverse events were observed. There were no changes in the blood dialysis parameters, although methylguanidine levels were significantly decreased at the end of study. Conclusion: The present study demonstrated the capacity of e-RO to preserve the viability of PMNs, and the clinical feasibility of applying this water for HD treatment. The clinical application of this technology may improve the bio-compatibility of HD treatment.
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