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绗竴锛?span style="COLOR: black" lang="EN-US">Major advance in a classic field, 鍋囧璇存槸涓€涓潪甯哥粡鍏哥殑瀛︾濡傜粍缁囪儦鑳庡锛堣鍖诲闄㈢殑浜猴紝閮借瀛︼級锛屽畠宸茬粡涓嶈兘鍐嶆湁寰堝ぇ杩涘睍鏃?span lang="EN-US">, 绐佺劧浣犳湁涓€涓噸澶х殑绐佺牬锛岃繖鏍风殑宸ヤ綔锛屽簲璇ユ槸鐩稿綋涓嶉敊鐨勩€?span style="COLOR: black">姣斿璇磋儐鍥洪唶锛屽ぇ瀹剁煡閬撹儐鍥洪唶涓€鑸璁や负鏄潖涓滆タ锛屼竴涓汉鐨勮儐鍥洪唶瑕佹帶鍒朵笉鑳藉お楂橈紝鍥犱负瀹冭閫犳垚蹇冭绠＄郴缁熺殑鐤剧梾銆備絾濡傛灉浣犵獊鐒跺彂鐜拌儐鍥洪唶鐨勫彟涓€涓敓鐞嗗姛鏁堬紝閭ｅ氨寰堜簡涓嶈捣銆傝繖涓緥瀛愪笉鏄贡涓剧殑锛屽湪1999 鑷?span lang="EN-US"> 2001骞翠腑锛岃繛缁湪Science鏉傚織涓婂彂琛ㄤ簡涓夌瘒鏂囩珷锛岃涓鸿儐鍥洪唶鍙互淇冭繘鑴戠缁忕粏鑳炵獊瑙︾殑褰㈡垚锛岃繖灏辩粰鑳嗗浐閱囧湪鐢熺悊鍔熻兘鐨勮璇嗗甫鏉ヤ簡涓€涓獊鐮存€х殑杩涘睍銆備綘鍘荤湅浠栦滑鐨勫伐浣滐紝瀹炲湪澶畝鍗曚簡锛屼竴鑸殑瀹為獙瀹ら兘鍙互鍋氾紝涓轰粈涔堝ぇ瀹堕兘鎯充笉鍒帮紵 涓€涓粡鍏哥殑鍙よ€佺殑瀛︾锛屽埌浜嗕笉鑳藉啀鏈変粈涔堝彂灞曠殑绋嬪害鏃讹紝鍙湁浠庝竴涓畬鍏ㄤ笉鍚岀殑瑙掑害鏉ョ湅闂锛?鎵嶈兘鏈夌獊鐮淬€?绐佺劧闂磋儐鍥洪唶鍙樻垚涓€涓潪甯哥儹闂ㄧ殑棰嗗煙锛屼粖澶╂湁浜鸿涓鸿儐鍥洪唶瀵圭缁忕粏鑳炵敓闀跨獊瑙︾殑褰㈡垚鏈変綔鐢紝鏄庡ぉ鍙堟湁浜鸿涓鸿儐鍥洪唶鎬庝箞鏍凤紝涓€涓嬪瓙涓€涓彜鑰佺粡鍏哥殑瀛︾锛屾湁浜嗕竴涓獊椋炵寷杩涚殑鍙戝睍銆?span lang="EN-US">

绗簩锛?span style="COLOR: black" lang="EN-US">New techniques and methods that can be widely used, 鎴戜滑鍦ㄥ仛鐮旂┒宸ヤ綔涓粡甯镐細鍙戠幇鏂扮殑鏂规硶鍜屾妧鏈€?span style="COLOR: black">涓€涓妧鏈拰鏂规硶瑕佽闈炲父骞挎硾鍦颁娇鐢?span lang="EN-US">,閭ｅ氨鏄竴涓緢濂界殑宸ヤ綔锛岀敋鑷冲彲浠ュ緱璇鸿礉灏斿銆?span lang="EN-US">PCR 鎶€鏈槸鑾疯璐濆皵濂栫殑锛?span lang="EN-US">PCR 鎶€鏈彂鏄庣殑褰撳勾锛屼竴涓嬪瓙灏辨湁鍑犲崄绡囨枃绔狅紝鍚庢潵鍒板閮界敤PCR锛岀幇鍦ㄥ凡缁忚闈炲父骞挎硾搴旂敤銆備笉杩囪繖浣嶅彂鏄?span lang="EN-US"> PCR 鐨勪汉锛?span lang="EN-US">Kary Mullis, 鎴戣寰椾笉鎬庝箞鏍枫€?浠栦粠姝ゅ氨涓嶅共绉戝涓嶅共娲伙紝鏁村ぉ鍒版捣婊╁幓鍐叉氮鐜┿€傚悗鏉ユ湁浜虹璐轰粬寰椾簡璇鸿礉灏斿锛屼粬璇存濂栨棭灏辫缁欎粬鐨勪簡锛岄偅鏄澶栬瘽銆備簨瀹炰笂锛屽簲鐢ㄨ繖涔堝箍娉涚殑鎶€鏈紝浣犲嚑涔庡彲浠ュ潗鐫€绛夎璐濆皵濂栥€傝繕鏈?span lang="EN-US">Patch Clamp锛岃啘鐗囬挸鎶€鏈紝鏈変簡杩欎釜鎶€鏈?span lang="EN-US">,鍦ㄧ數鐢熺悊鏂归潰瀹屽叏鏀逛簡涓牱锛屼笉浠呮槸绁炵粡缁嗚優锛岃繕鐢ㄥ埌蹇冭倢缁嗚優绛夊悇绉嶅悇鏍风殑缁嗚優锛岄兘鍙互鐢?span lang="EN-US">Patch Clamp鎶€鏈紝鏉ヨ褰曠數淇″彿鍙樺寲銆傚彂鏄庤鎶€鏈殑浜轰篃寰椾簡璇鸿礉灏斿銆傛垜棰勬祴鏈夊彲鑳藉緱璇鸿礉灏斿鐨勬槸浜虹被鍩哄洜鐮旂┒涓殑鑷姩娴嬪簭鎶€鏈紝搴旂敤闈炲父骞挎硾锛岃€屼笖璁稿宸ヤ綔鍙互鎻愬墠濂藉骞村畬鎴愩€傝繖鏍风殑鎶€鏈€佹柟娉曪紝鍙互璇存槸涓€涓潪甯稿ソ鐨勫伐浣溿€傛湁鏃跺€欒闈炲父骞挎硾寮曠敤鐨勬妧鏈€ф枃绔狅紝杩樹笉涓€瀹氭槸鍙戣〃鍦?span lang="EN-US">Science銆?span lang="EN-US">Nature鏉傚織涓婏紝鎴戜滑涔熶笉鑳界敤Science銆?span lang="EN-US">Nature涓婂彂琛ㄨ鏂囩殑鏍囧噯鏉ヨ　閲忋€傛瘮濡?span lang="EN-US">Patch Clamp鎶€鏈殑鏂囩珷灏辨槸鍙戣〃鍦ㄤ竴涓綘鍙兘閮芥病鏈夊惉璇磋繃鐨勬潅蹇椾笂銆?span lang="EN-US">

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绗竴锛?span style="COLOR: black" lang="EN-US">Horizontal growth锛屽彨鍋氭í鍚戦暱锛岃繖绫绘枃绔犲湪鍥藉唴寰堝銆傚鏋滀竴涓汉锛岃妯潃闀挎€庝箞涔熶笉浼氬ソ鐪?锛堢瑧锛夈€備妇渚嬶紝浣犲湪澶ч紶涓婂緱鍒颁竴涓彂鐜帮紝閭ｆ垜鍦ㄥ皬榧犱笂涔熷仛涓€涓嬶紝涔熸湁鍚屾牱鐨勫彂鐜帮紝杩欏氨娌℃湁鍒涙柊鎰忎箟銆傝繖涓緥瀛愭湁鐐硅繃鍒嗭紝褰撶劧濡傛灉浣犳槸鍦ㄨ€侀紶韬笂鍋氾紝鑰屽湪浜鸿韩涓婁粠鏉ユ病鏈夊仛杩囷紝鎴戞潵鍋氫竴涓嬶紝閭ｅ簲璇ヤ篃鏄湁鎰忎箟鐨勩€?span lang="EN-US">

绗簩锛?span lang="EN-US">Filling gaps锛屾湁浜哄彂鐜颁簡A锛岀寽鎯?span lang="EN-US">A浼氬埌B锛屾湁浜哄彂鐜颁簡C锛屼綘灏卞湪涓棿璇佸疄涓€涓?span lang="EN-US">A鏄€氳繃B鍒?span lang="EN-US">C鐨勩€傝繖鏍风殑鍙戠幇锛屼篃涓嶆槸璇翠笉鍙互鍙戣〃鏂囩珷锛屼絾杩欑鏂囩珷涓嶄細鍦ㄥ緢鍑鸿壊鐨勬潅蹇椾笂鍙戣〃锛屽洜涓烘潅蹇楃殑缂栧涓€鐪嬭繖绉嶆枃绔犲氨璁や负鏄竴绉?span lang="EN-US">Filling gaps銆備妇渚嬶紝宸茬煡EGF鍙互婵€娲?span lang="EN-US">JNK锛?span lang="EN-US">JNK鍙互閫犳垚C-Jun鐨勮〃杈撅紝鍋囧浣犲彂琛ㄤ竴绡囨枃绔犲幓璇?span lang="EN-US">EGF鍙互淇冭繘C-Jun鐨勮〃杈撅紝閭ｄ汉瀹跺凡缁忕煡閬?span lang="EN-US">JNK鍙互淇冭繘C-Jun鐨勮〃杈撅紝EGF鍙互婵€娲?span lang="EN-US">JNK锛屽綋鐒跺鏋滀汉瀹舵病鏈夊仛鍑烘潵锛岃繖涔熸槸涓€绉嶅彂鐜帮紝浣嗚繖绉嶅彂鐜颁笉鏄偅涔?span lang="EN-US">exciting锛岃繖绫绘枃绔犲睘浜庡～琛ョ┖缂虹殑鏂囩珷銆?span lang="EN-US">

绗笁锛?span lang="EN-US">Working out details锛屾湁浜烘妸澶х殑妗嗘灦宸茬粡鎼炲嚭鏉ヤ簡锛屼綘鎶婄粏鑺傚啀鎼炴竻妤氱殑鏂囩珷锛屼竴鑸笉浼氭槸鐗瑰埆濂界殑鏂囩珷銆傛垜浠婂ぉ璁茬殑涓嶆槸鍧忔枃绔狅紝閭ｆ垜鎻愪篃涓嶆彁锛屽彧鏄杩欑被鏂囩珷杩樺彲浠ュ湪浜屾祦鎴栦笁娴佹潅蹇椾笂鍙戣〃锛岃繖鏄笌鍓嶉潰璁茬殑濂界殑宸ヤ綔鏈変釜鍙嶅樊銆備妇渚嬶紝鍙戠幇涓€涓?span lang="EN-US">NO锛堜竴姘у寲姘級鏄釜寰堥噸瑕佺殑淇″彿鍒嗗瓙锛屽彂鐜拌€呬篃寰椾簡璇鸿礉灏斿銆?span lang="EN-US">NO鑳戒骇鐢?span lang="EN-US">cGMP锛岀劧鍚庝綘鍋氫簡涓€绡囨枃绔狅紝璇存槸鐢ㄥ灏戞椂闂达紝鎬庢牱鐨勬祿搴︼紝浣?span lang="EN-US">NO浜х敓cGMP锛岃繖绫诲伐浣滄€绘槸瑕佹湁浜哄幓鍋氾紝浣嗚繖涓嶄細鏄竴涓渶閲嶈鐨勮础鐚€?span lang="EN-US">

绗洓锛?span lang="EN-US">Support existing idea, “me too”锛岃繖绫绘枃绔犲緢澶氾紝鏈変簺浜烘枃鐚湅寰楀緢澶氾紝鑰屼笖鎵嬭剼鐗瑰埆蹇紝绛変綘鐨勬枃绔犲湪Science銆?span lang="EN-US">Nature涓婁竴鍙戣〃锛屼粬椹笂璺熶笂涓€绡?ldquo;me too”锛屼綘浼氾紝浠栦篃浼氥€備妇渚嬶紝EGF鍙椾綋鍚炲櫖鏃讹紝闇€瑕?span lang="EN-US">dynamin, 宸插湪Science鏉傚織涓婂彂琛紝鏈変汉椹笂鍙戣〃PDGF鍙椾綋涔熸槸闇€瑕?span lang="EN-US">dynamin锛屽叾瀹?span lang="EN-US">EGF-R涓?span lang="EN-US">PDGF-R铏界劧鍙椾綋瀹屽叏涓嶄竴鏍凤紝浣嗛兘鏄釜閰皑閰搁叾鐨勫彈浣擄紝杩欎袱涓彈浣擄紝浣犵寽鐚滃氨鍙互鐭ラ亾銆傝繖绉嶅伐浣滃彲浠ュ彂琛紝浣嗕笉浼氬彂琛ㄥ湪鏈€濂界殑鏉傚織锛岄櫎闈炲畠鍦?span lang="EN-US">PDGF鐮旂┒棰嗗煙涓湁鐗规畩鎰忎箟銆?span lang="EN-US">

绗簲锛?span lang="EN-US">Follow up锛屾湁浜哄湪鍓嶉潰宸茬粡鍙戣〃浜嗭紝鎴戝湪鍚庨潰璺熶笂銆備妇渚嬶紝CREB鏄竴涓緢閲嶈鐨勮浆褰曞洜瀛愶紝瀹冨彲浠ョ粨鍚堝埌DNA鐨勪竴涓垚鍒嗕笂锛岃繖涓垚鍒嗗彨CRE锛岃繖鏄竴涓緢閲嶅ぇ鐨勫彂鐜帮紝CREB鍙互缁撳悎鍒?span lang="EN-US">CRE锛岃繃浜屽ぉ浠栦篃鍙戣〃涓€绡囨枃绔狅紝涓€鍏遍渶瑕佸嚑涓?span lang="EN-US">base锛岀涓€浠庡摢閲屽紑濮嬶紝鏈€鍚庡埌鍝噷缁撴潫锛岃繖閲岄潰鍒板簳瑕佸嚑涓⒈鍩猴紝A瑕佸灏戜釜锛岃鎹㈡帀鐨勮瘽binding灏变細涓嶅ソ銆傝繖绉嶅伐浣滀笉鏄畬鍏ㄤ笉閲嶈锛屼絾灞炰簬Follow up銆?span lang="EN-US">

绗叚锛?span lang="EN-US">Incomplete study, preliminary锛岃繖绫绘枃绔犳渶浠や汉璁ㄥ帉锛屽浗鍐呰繖鏍风殑鏂囩珷寰堝锛屾娲蹭篃澶氾紝杩樻湁鏃ユ湰銆傚仛浜嗕簩涓浘鎴栧洓涓浘锛屾湁杩欎箞涓€鐐圭偣鐨勭幇璞★紝鏁呬簨杩樻病鏈夎瀹岋紝椹笂灏遍€佸幓鍙戣〃銆傝繖绫绘枃绔犲湪浜屼笁娴佹潅蹇椾篃涓嶄細鎷掔粷锛屾€诲綊鏄竴涓彂鐜般€傝繖绉嶆妸鏁呬簨璁蹭簡涓€鍗婏紝浣犳妸鐜拌薄鎼炴帀浜嗭紝浣垮緱浜哄涔熶笉鑳藉幓鍋氫竴涓畬鏁寸殑宸ヤ綔銆傛垜瑙夊緱杩欑鏂囩珷鏄樆纰嶄簡绉戝鐨勫彂灞曪紝灏辫薄鍐欏皬璇翠竴鏍凤紝浣犲啓浜嗙涓€鑺傦紝璁╁埆浜哄幓鍐欑浜屻€佺涓夎妭锛屼汉瀹朵笉浼氭効鎰忓幓鍋氥€傛垜鏄緢璁ㄥ帉杩欑被鏂囩珷鐨勶紝纰板埌杩欑鏂囩珷锛屾垜鍋氬绋挎椂浼氳浠栫户缁幓鍋氾紝浣嗕笉浼氭嫆缁濓紝鍚﹀垯浠栦細鍘绘姇鍒殑鏉傚織銆傛垜浼氬紑涓竻鍗?span lang="EN-US">1锛?span lang="EN-US">2锛?span lang="EN-US">3锛?span lang="EN-US">4,….锛屽浠栬锛岀瓑浣犳妸杩欎簺宸ヤ綔鍏ㄩ儴鍋氬畬锛屼篃浼氬嚭涓€绡囦笉閿欑殑鏂囩珷銆傛垜缁忓父鐢ㄨ繖绉嶆柟寮忔潵瀵瑰緟杩欑被鏂囩珷銆傚湪鏃ユ湰锛屽湪涓浗锛屽緢澶氫汉鍦ㄥ帇鍔涗箣涓嬶紝閮借鍦?span lang="EN-US">SCI鍑犵偣鍑犲垎鏉傚織涓婂彂琛ㄦ枃绔狅紝鎵嶅彲浠ユ嬁鍗氬＋瀛︿綅銆?span lang="EN-US">

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