科学网-刘天伟的博客-[转载]八、为了造福全球疟疾病人--- 《迟到的报告》
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瀛﹁€呭垬澶╀紵 鍙戣〃浜?010-5-29 22:23:14
锛? 鈹? 娴忚锛?3      

[杞浇]鍏€佷负浜嗛€犵鍏ㄧ悆鐤熺柧鐥呬汉 --- 銆婅繜鍒扮殑鎶ュ憡銆?/span>

[鍘熶功p87-108]

1銆佸鍚庡弽鎬濆叴涓氶』闈犺嚜寮?/span>

鍦ㄨ繖娆″浗闄呭悎浣滄椿鍔ㄤ腑锛屾垜浠繁鎰熷鑽搧鐨勫浗闄呮爣鍑嗙煡涔嬪お灏戙€傜敱姝わ紝鎴戜滑涔熷紑濮嬭璇嗗埌锛屾柊鑽爺鍒跺紑鍙戝涓嶄笌鍥介檯鎺ヨ建锛屽氨璧颁笉鍑哄浗闂紝杩涘叆涓嶄簡鍥介檯甯傚満銆?/span>

铏界劧锛屼笌WHO鍜岀編鍥藉崕灏旂壒閲屽痉鐮旂┒闄㈠悎浣滅爺绌堕潚钂跨惀閰繘灞曞緱涓嶅椤哄埄锛岀粨灞€涔熶笉灏戒汉鎰忥紝浣嗙敱浜庨潚钂跨礌鎸囧濮斿憳浼氬湪鍚堜綔璋堝垽鍒濇湡锛屽挨鍏舵槸鍦ㄨ嵂鍘?/span>GMP妫€鏌ラ伃閬?ldquo;绾㈢伅”涔嬪悗锛屽繁棰勬枡鍒板湪鏈潵鍚堜綔涓殑澶嶆潅鎬у拰涓嶅彲棰勬祴鎬э紝鏋滄柇閲囧彇浜?ldquo;涓ゆ潯鑵胯蛋璺?rdquo;鐨勬柟閽堬紝渚濋潬鍏ㄥ浗澶у崗浣滅殑浼樺娍锛岃鐪熷涔犳帉鎻?/span>WHO鎻愪緵鐨勫浗闄呮爣鍑嗕笌鎶€鏈柟娉曪紝鍔犱笂寰楀埌鍥藉璐㈡斂閮ㄧ殑涓撴鏀寔锛屾渶缁堣繕鏄鏈熷湴瀹屾垚浜嗛潚钂跨惀閰拰钂跨敳閱氱殑寮€鍙戠爺绌讹紝骞堕『鍒╁湴閫氳繃浜嗗浗瀹惰嵂鏀块儴闂ㄧ殑瀹℃煡鎵瑰噯銆傝繖鏄垜鍥芥寜鐓у浗闄呮爣鍑嗗紑鍙戞柊鑽殑涓€娆″皾璇曪紝涔熸槸瀵规垜鍥芥柊鑽紑鍙戠鎶€鍔涢噺鐨勪竴娆¤€冮獙銆?/span>

鎴戝浗鏂拌嵂璇勪环涓庡鎵圭鐞嗗埗搴︼紝鍦?/span>20涓栫邯80骞翠唬鍒濇湡灏氫笉鍋ュ叏銆傚綋鏃讹紝鎴戝浗灏氭棤涓撻棬浠庝簨涓村簥鑽悊鐮旂┒鐨勬満鏋勶紝涓村簥鑽悊绉戞妧浜哄憳鍔涢噺钖勫急锛屼复搴婂墠鑽悊姣掓€э紝鐗瑰埆鏄壒娈婃瘨鎬х殑鐮旂┒鍑犱箮鏄┖鐧姐€傛垜鍥藉埗鑽巶鐢熶骇鐨勯潚钂跨礌绫绘姉鐤熻嵂涓嶈兘涓哄浗闄呮墍鍏銆?/span>

鍏充簬闈掕捒绱犳姉鐤熻嵂鐨勫畨鍏ㄦ€ч棶棰橈紝鍏ㄥ浗523棰嗗灏忕粍鍜屽悗鏉ョ殑闈掕捒绱犳寚瀵煎鍛樹細閮介潪甯搁噸瑙?/span>[50]銆?/span>1981骞达紝鎴戝浗杩樻病鏈夊疄鏂?/span>GLP绠$悊瑙勮寖锛屾病鏈変竴涓悎鏍肩殑GLP瀹為獙瀹わ紝浣嗘槸宸茬粡浜嗚В鍒板浗闄呬笂瀵硅嵂鐗╁畨鍏ㄦ€ц瘎浠风殑姣掓€ц瘯楠岋紝蹇呴』鍦?/span>GLP瑙勮寖绠$悊鐨勫疄楠屽鍐呰繘琛岋紱鍥犳灏辨寜鐓?/span>GLP鎰忚瘑鍜岃姹傛瘮杈冪郴缁熷湴杩涜浜嗛潚钂跨礌娌规贩鎮墏瀵瑰ぇ鍔ㄧ墿锛堢尨锛夌殑14澶╅暱鏈熸瘨鎬ц瘯楠屻€傜粨鏋滆〃鏄庯紝3鍊嶄复搴婃不鐤楀墏閲忕粍鐨勭尨瀛愭棤浠讳綍姣掓€у弽搴旓紝6鍊嶅墏閲忕粍锛?/span>48MKD锛夌殑鍔ㄧ墿鍑虹幇涓€杩囨€х殑缃戠粐绾㈢粏鑳炲噺灏戯紝瓒呰繃12鍊嶅墏閲忕粍锛?/span>96MKD锛夌殑鍔ㄧ墿鎵嶅嚭鐜版槑鏄炬瘨鎬у弽搴斻€傛瘨鎬ц〃鐜颁负閫犺鍔熻兘涓ラ噸鎶戝埗锛屽績鑲屽彈鎹燂紝鍑虹幇浜嗙缁忔瘨鎬э紝1/6鍔ㄧ墿姝讳骸浜庡績鍔涜“绔€傛寜鐓т笂杩版瘨鎬у墏閲忚璁℃柟妗堬紝鍙堢敤鐙楀仛浜?/span>14澶╃殑闀挎瘨璇曢獙锛屽叾缁撴灉涓庣尨瀛愮殑姣掓€у弽搴旂被鍚岋紝浣嗙棁鐘惰緝杞伙紝鏃犲姩鐗╂浜°€傚洜姝わ紝鍙互璁や负锛岄潚钂跨礌瀵规不鐤楁姉鑽€ф伓鎬х枱鐤惧拰浣滀负閲嶇棁鐤熺柧鐨勬€ユ晳鑽槸鏈€瀹夊叏鐨勩€?/span>

姝ゅ悗锛岄潚钂跨礌鎸囧濮斿憳浼氫究鍊熷姪WHO鐤熺柧鍖栫枟绉戝宸ヤ綔缁勬彁渚涚殑鐮旂┒璁捐鏂规鍜屾潵鍗庝笓瀹剁殑鎸囧锛屼簬20涓栫邯80骞翠唬鍒濇湡锛屽湪鍥藉唴鐜囧厛鎸夌収鍥介檯鏍囧噯瀵归潚钂跨礌绫绘姉鐤熻嵂杩涜鐮旂┒锛屽紑鍒涗簡鎴戝浗鎸夌収鍥介檯鏍囧噯鐮斿彂鏂拌嵂鐨勫厛娌炽€傚湪涓€浜涢鍩熷~琛ヤ簡绌虹櫧銆?/span>

涓尰鐮旂┒闄腑鑽墍鑽悊鐮旂┒瀹ょ敱鏉庢辰鐞虫暀鎺堜富鎸侊紝寮€灞曚簡闈掕捒绱犵被鎶楃枱鑽嚧绐佸彉鍜岀敓娈栨瘨鎬ц瘯楠岀爺绌讹紝娑堥櫎浜嗕汉浠闈掕捒绱犵被鑽墿鍙兘鍙戠敓绫讳技20涓栫邯60骞翠唬鍦ㄥ痉鍥藉彂鐢熺殑“鍙嶅簲鍋滀簨浠?rdquo;鎮插墽閲嶆紨鐨勬媴蹇冦€?/span>1983骞存浘缇庢€℃暀鎺堥槓鏄庝簡绱鍒嗗厜鍏夊害娉曟祴瀹氶潚钂跨礌鍖栧鍙嶅簲鏈虹悊锛?/span>1986骞磋档涓栧杽鍦?/span>姝ゅ熀纭€涓?/span>锛屽湪鍥藉唴棣栧厛寤虹珛浜嗛潚钂跨礌楂樻晥娑茬浉鑹茶氨娉曪紝鎴愬姛鍦扮敤浜庡姩鐗╁拰浜轰綋琛€娴嗗拰鍞炬恫浠ュ強妞嶇墿涓潚钂跨礌鐨勬祴瀹氾紱鍛?/span>閽?/span>楦f暀鎺堢巼鍏堝湪鍥藉唴涓村簥涓婂鐤熺柧鎮h€呯敤闈掕捒绱犳爴鍚庣殑鑽墿浠h阿鍔ㄥ姏瀛︾殑鐮旂┒銆?/span>1986骞存浘缇庢€℃暀鎺堝缓绔嬩簡鏈姶閱囩殑楂樻晥娑茬浉鑹茶氨娉曪紝涓轰互鍚庝汉浣撹娴嗘祿搴︽祴瀹氬瀹氫簡鍩虹銆?/span>

鍐涗簨鍖诲绉戝闄㈠井鐢熺墿娴佽鐥呯爺绌舵墍鑽悊姣掔悊鐮旂┒瀹わ紝鐢辨粫缈曞拰鏁欐巿涓绘寔寮€灞曠殑闈掕捒绱犵被鎶楃枱鑽暱鏈熸瘨鎬ц瘯楠岀爺绌讹紝涓哄姏姹傝揪鍒?/span>GLP瑙勮寖鍖栬姹傦紝鍦ㄧ粍缁囩鎶€浜哄憳鎶€鏈粌鍏电殑鍚屾椂锛岃崏鎷熶簡姣掓€у疄楠屻€佹楠岄」鐩悇绉嶆爣鍑嗗寲鎿嶄綔瑙勭▼锛?/span>SOP)锛屼负鏈€鍚庡疄楠岀爺绌跺伐浣滄€荤粨鎻愪緵浜嗗畬鏁淬€佺瀛﹁€屼笖鏈夎鏈嶅姏鐨勬暟鎹祫鏂欙紝鍙楀埌鑽墿璇勫閮ㄩ棬鐨勯珮搴﹁瘎浠枫€傝繖涔熸槸鍥藉唴棣栨鎸?/span>GLP瑙勮寖鐨勮姹傚鑽墿杩涜涓村簥鍓嶅畨鍏ㄦ€ц瘎浠枫€?/span>

鍐涗簨鍖诲绉戝闄㈡斁灏勫尰瀛︾爺绌舵墍瀹嬩功鍏冩暀鎺堝湪鍔ㄧ墿鐨勬瘨鐞嗚瘯楠岀爺绌朵腑锛岀粡杩囦粩缁嗙殑瑙傚療锛屽彂鐜板ぇ鍓傞噺闈掕捒绱犲彲浣垮疄楠屽姩鐗╃殑鏃╂湡缃戠粐绾㈢粏鑳炴暟涓嬮檷銆傝繖涓€鍙戠幇鎴愪负鍚庢潵闈掕捒绱犵被鑽复搴婄敤鑽瘨鎬х洃娴嬬殑閲嶈鎸囨爣鏂规硶涔嬩竴銆?/span>

涓浗鍖诲绉戝闄㈣嵂鐗╃爺绌舵墍锛岀敱瀹嬫尟鐜夊拰鏉ㄦ爲寰锋暀鎺堜富鎸佸紑灞曚簡闈掕捒绱犵被鎶楃枱鑽复搴婅嵂浠e姩鍔涘鐨勭爺绌讹紝寤虹珛鐨勬斁灏勫厤鐤祴瀹氭硶鍜岃繕鍘熷瀷鐢靛寲瀛︽瀬璋辨娴嬮珮鏁堟恫鐩歌壊璋辨硶锛?/span>HPLC-Ee)锛屼负鍒跺畾涓村簥缁欒嵂鏂规鎻愪緵浜嗙瀛︿緷鎹€?/span>

骞垮窞涓尰瀛﹂櫌鐤熺柧鐮旂┒瀹わ紝鐢辨潕鍥芥ˉ鏁欐巿涓绘寔寮€灞曠殑闈掕捒绱犵被鎶楃枱鑽?/span>I鏈熶复搴婅瘯楠岋紝浠ュ仴搴蜂汉涓鸿瘯楠屽璞★紝瑙傚療浜嗚В鑽墿涓村簥鐨勪笉鑹弽搴斿拰鑰愬彈鎬с€傝繖鍦ㄦ垜鍥借繃鍘荤殑涓村簥鐮旂┒鏄棤鍏堜緥鐨勩€備负浜嗕笌鍥介檯鎺ヨ建锛屽浗瀹跺崼鐢熼儴鑽斂灞€鎵瑰噯鐢卞箍宸炰腑鍖诲闄㈣礋璐g粍缁囧疄鏂姐€傝瘯楠岀洃鐫d汉锛?/span>monitor)鐢卞崼鐢熼儴鑽鎵€鏈辩嚂鎷呬换銆傝繖鏄垜鍥介娆℃寜鐓?/span>WHO 鎻愪緵鐨勯潚钂跨惀閰€佽捒鐢查啔I鏈熶复搴婅瘯楠岃璁℃柟妗堬紝瀵瑰仴搴锋垚浜哄織鎰胯€呰繘琛岃€愬彈鎬у拰鑽唬鍔ㄥ姏瀛︾殑鍙岀洸璇曢獙銆?/span>

涓鸿繘涓€姝ユ帉鎻″浗闄呰嵂鐗╂敞鍐屽鐢虫姤鏂囦欢璧勬枡鐨勮姹傦紝鍦ㄥ浗瀹跺尰鑽鐞嗗眬娌堝绁ユ暀鎺堟寚瀵间笅锛岄潚钂跨礌鎸囧濮斿憳浼氱粍缁囨粫缈曞拰銆侀倱钃変粰銆佽档绉€鏂囥€佹浘缇庢€℃暀鎺堢瓑锛屾寜鐓у浗闄呰嵂鐗╂敞鍐岃鏍间笌瑕佹眰锛屽闈掕捒鐞ラ叝銆佽捒鐢查啔鐨勭敵鎶ユ敞鍐屾潗鏂欒繘琛屼簡鍏ㄩ潰淇敼鍜岄€氱瘒缈昏瘧锛岃WHO鐤熺柧鍖栫枟绉戝宸ヤ綔缁勭殑鐭ュ悕涓撳鍜岄【闂崗鍔╁鏌ャ€備粬浠彁鍑轰簡寰堝鏈夌泭鐨勬剰瑙佸拰寤鸿銆?/span>

缁忚繃10澶氬勾鐨勬帰绱㈢爺绌跺拰鍚勬湁鍏冲崟浣嶉€氬姏鍚堜綔锛屼粠闈掕捒绱犳敼閫犺鐢熷嚭鏉ョ殑钂跨敳閱氱殑娌归拡鍓傚拰闈掕捒鐞ラ叝鐨勬按閽堝墏锛屼簬1987 骞磋鍥藉鍗敓閮ㄦ壒鍑嗙敓浜с€?/span>1987 骞?/span>9鏈?/span>11鏃ワ紝鍥藉鍗敓閮ㄤ负姝ゅ彫寮€鏂伴椈鍙戝竷浼氾紝瀹e憡钂跨敳閱氥€侀潚钂跨惀閰拡鍓傚拰闈掕捒绱犳爴鍓傦紝浣滀负娌荤枟鎶楄嵂鎬ф伓鎬х枱鍜屾姠鏁戣剳鍨嬬枱鐥呬汉鐨勭壒鏁堣嵂鐮斿埗鎴愬姛锛屽紑濮嬫姇鍏ュ競鍦?/span>[51][52]銆?/span>1992骞达紝鎴戝浗鍙堟壒鍑嗕簡鍙屾阿闈掕捒绱犵墖鍓傚拰钂跨敳閱氾紞鏈姶閱囧鏂规姇浜с€?/span>1998~2004骞达紝鍥藉鑽搧鐩戠潱绠$悊灞€鍙堝厛鍚庢壒鍑嗛鍙戜簡闈掕捒绱狅紞钀橀厷鍠瑰鏂广€佸弻姘㈤潚钂跨礌锛嶅搶鍠圭郴鍒楀鏂圭瓑澶氫釜鏂拌嵂璇佷功鍜岀敓浜ф壒浠?/span>銆?/span>

浠?/span>1985骞存垜鍥藉紑濮嬪疄琛屾柊鑽瘎瀹¤瀹氬埌1995骞达紝鍏ㄥ浗鎬诲叡鎵瑰噯涓€绫绘柊鑽?/span>14涓紝鍏朵腑闈掕捒绱犵被鎶楃枱鏂拌嵂灏卞崰浜?/span>7涓€傝繖鍏呭垎璇存槑涓庡浗闄呮帴杞ㄥ鏂拌嵂鐮旂┒鎵€璧嬩簣鐨勬椿鍔涳紝鍚屾椂涔熻〃鏄庨潚钂跨礌绫昏嵂鍦ㄦ垜鍥芥柊鑽爺绌跺巻鍙蹭腑鎵€鍗犵殑鍦颁綅銆?/span>

2銆侀涓惃绾ч潚钂跨礌宸ュ巶寤烘垚

鏃╁湪1978骞寸敱鍥藉鍗敓閮ㄣ€佸尰鑽鐞嗘€诲眬銆佽В鏀惧啗鎬诲悗鍕ら儴鑱斿悎鍙戞枃涓嬭揪绱ф€ョ敓浜ч潚钂跨礌浠诲姟鐨勮繃绋嬩腑锛岃櫧鐒讹紝鏈夊叧鍗曚綅杈冨ソ鍦板畬鎴愪簡鎴樺鐢ㄨ嵂鐨勭敓浜т换鍔★紝浣嗕篃鍙戠幇瀛樺湪涓€浜涗簾寰呰В鍐崇殑闂銆備竴鏄闈掕捒璧勬簮鎺屾彙鍜屽偍澶囧緱杩樹笉澶熷叏闈紱浜屾槸鍘熸湁鐨勫嚑绉嶆彁鍙栧伐鑹轰笌宸ヤ笟鍖栬妯$敓浜х殑鏉′欢浠嶆湁杈冨ぇ宸窛銆傚洜姝わ紝灏藉揩寤虹珛闈掕捒绱犲伐涓氬寲鐢熶骇鐨勮鏂斤紝琚彁鍒版湁鍏抽儴闂ㄥ叿浣撶殑璁簨鏃ョ▼銆?/span>

20涓栫邯70骞翠唬缁勭粐鐨勫叏鍥介潚钂胯祫婧愯皟鏌ワ紝宸辩粡鍙戠幇鍥涘窛鐪侀厜闃冲湴鍖虹殑閲庣敓闈掕捒鐨勮暣钘忛噺澶с€佸搧璐ㄤ紭鑹€侀潚钂跨礌鍚噺杈冮珮锛屼笖鍛堢兢钀藉垎甯冪殑鐗圭偣銆傚綋鏃堕潚钂跨礌鐨勭鐮斻€佷复搴婇渶瑕佺殑闈掕捒绱犲師鏂欙紝澶ч儴鍒嗘槸浠庢潵鑷厜闃冲湴鍖虹殑闈掕捒鑽夋彁鍙栫殑銆傞潚钂跨礌鎸囧濮斿憳浼氳€冭檻鍒板紑鍙戝拰淇濇姢閰夐槼鍦板尯鐨勪紭璐ㄩ潚钂胯祫婧愶紝瀵瑰疄鐜版垜鍥介潚钂跨礌鍙婂叾琛嶇敓鐗╀骇鍝佸晢涓氬寲鐨勯噸瑕佹剰涔夛紝浜?/span>1983~1984骞存嫧涓撴锛岀粍缁囩鎶€浜哄憳寮€灞曢厜闃冲湴鍖轰紭璐ㄩ潚钂胯祫婧愮殑璋冩煡锛屽苟灏卞湪閰夐槼寤虹珛闈掕捒绉嶆鍩哄湴鍜岄潚钂跨礌宸ヤ笟鍖栫敓浜у巶鍙鎬х殑鐮旂┒銆?/span>

鍦ㄩ潚钂跨礌鎸囧濮斿憳浼氱殑寤鸿鍜屾帹鍔ㄤ笅锛?/span>1986骞?/span>7鏈堬紝鍥涘窛鐪侀厜闃冲幙寮€濮嬬寤洪潚钂跨礌鎻愮偧鍘傘€備负浜嗕繚璇佹垜鍥借嚜琛岀爺绌惰璁$殑绗竴涓惃绾ч潚钂跨礌宸ヤ笟鍖栧伐鍘傜敓浜у伐鑹虹殑鎬ц兘锛屽悓鏃惰€冭檻鍒伴厜闃冲湴鍖哄浜庤传鍥板北鍖虹己涔忔妧鏈拰缁忚垂锛屾牴鎹紭鍔夸簰琛ョ殑绮剧锛岄潚钂跨礌鎸囧濮斿憳浼氭嫧涓撴鏀寔灞变笢鐪佷腑鍖昏嵂鐮旂┒鎵€鐮旂┒闈掕捒绱犵殑鐢熶骇宸ヨ壓鍜岃В鍐虫闄靛北鍒惰嵂鍘傜殑鐢熶骇璁惧锛屽悓骞?/span>11鏈堢敱鍥涘窛鐪佸尰鑽鐞嗗眬鍜岀渷鍗敓鍘呮壒鍑嗘垚绔嬩簡姝﹂櫟灞卞埗鑽巶銆?/span>1987骞?/span>7鏈堬紝姝﹂櫟灞卞埗鑽巶涓庡北涓滅渷涓尰鑽爺绌舵墍绛捐浜嗐€婇潚钂跨礌鍘熸枡鑽敓浜х殑宸ヨ壓鎶€鏈浆璁╁悎鍚屻€嬶紝缁忚繃闈掕捒绱犲伐涓氬寲鐢熶骇鐨勫皬璇曞拰涓瘯锛屾垚鍔熺敓浜у嚭鍚堟牸鐨勯潚钂跨礌浜у搧銆傚浗瀹跺崼鐢熼儴銆佸浗瀹跺尰鑽鐞嗗眬浜?/span>1987骞?/span>9鏈堝湪鏂伴椈鍙戝竷浼氬甯冿紝鎴戝浗鍚ㄧ骇鐨勯潚钂跨礌鍘傚缓鎴愭姇浜с€傚畠鏄垜鍥戒篃鏄笘鐣岀涓€涓伐涓氬寲鐢熶骇闈掕捒绱犲伐鍘傘€?/span>

涓轰簡鎵╁ぇ闈掕捒绱犱骇鑳斤紝瑙e喅钂跨敳閱氱瓑缁堢浜у搧鐨勫師鏂欐潵婧愶紝鍦ㄩ潚钂跨礌鎸囧濮斿憳浼氱殑鏀寔鍗忚皟涓嬶紝鏄嗘槑鍒惰嵂鍘備笌鍥涘窛姝﹂櫟灞卞埗鑽巶缁忚繃鍗忓晢锛屽弻鏂瑰悓鎰忓缓绔嬬敓浜ч潚钂跨礌鐨勫悎浣滃叧绯伙紝骞剁璁簡鑱斿悎鐢熶骇闈掕捒绱犵殑鍗忚銆傚崗璁槑纭敱鏄嗘槑鍒惰嵂鍘傝礋璐f妸濂介潚钂跨礌鐨勭敓浜ц川閲忓叧锛屽苟鍚戞闄靛北鍒惰嵂鍘傛姇璧?/span>20涓囧厓銆傛湁鍔涘湴鎺ㄨ繘浜嗘垜鍥介潚钂跨礌鐨勪骇涓氬寲銆?/span>1987骞?/span>12鏈堬紝鍥涘窛鐪佹丢闄靛湴鍖烘壒鍑嗘闄靛北鍒惰嵂鍘傛柊寤洪潚钂跨礌杞﹂棿銆?/span>1988骞村厓鏃︼紝杞﹂棿鐮村湡鍔ㄥ伐銆?/span>1990骞村湪涓婄骇棰嗗閮ㄩ棬鐨勫叧鎬€鍜屽ぇ鍔涙敮鎸佷笅锛屼竴涓璁″勾浜ч噺鏇村ぇ鐨勯潚钂跨礌宸ヤ笟鍖栨彁鐐艰溅闂村缓鎴愭姇浜с€?/span>

姝﹂櫟灞卞埗鑽巶闈掕捒绱犵殑鎶曚骇锛屽鎺ㄥ姩鎴戝浗闈掕捒绱犲強鍏惰鐢熺墿璧板悜涓栫晫鍒涢€犱簡鏉′欢锛屽叿鏈夊巻鍙叉€х殑鎰忎箟銆?/span>

3銆佽矾婕极绉戝伐璐稿叡鍚屾墦甯傚満

闈掕捒绱犺鐢熺墿鐨勭爺绌朵笌寮€鍙戞槸涓€椤归珮绉戞妧銆佸鍚戞€с€佺宸ヨ锤涓夌粨鍚堢殑绯荤粺宸ョ▼锛岄暱鏈熶互鏉ヤ竴鐩村湪鍏ㄥ浗523鍔炲叕瀹ゃ€侀潚钂跨礌鎸囧濮斿憳浼氬強鍥藉鏈夊叧閮ㄩ棬鐨勭粺涓€棰嗗涓庡崗璋冧笅杩涜銆?/span>

闈掕捒绱犵被鏂拌嵂鍥介檯甯傚満鐨勫紑鍙戯紝鐢变簬鍙楁姇璧勫ぇ銆佹爣鍑嗛珮銆佹妧鏈€ц兘寮虹瓑鍥犵礌鍒剁害锛屼笉璁烘槸瀵规垜鍥藉埗鑽敓浜т紒涓氳繕鏄鐮斿崟浣嶏紝鍦ㄥ綋鏃堕兘鏄棦闄岀敓鍙堜妇姝ョ淮鑹扮殑浜嬨€傛洿閲嶈骞朵负澶у鎵€鎷呭績鐨勶紝鍥藉鐮旂┒寮€鍙戦潚钂跨礌鐑疆鐨勫叴璧凤紝浣挎垜鍥界殑闈掕捒绱犱骇涓氶潰涓寸潃涓ュ郴鐨勬寫鎴橈紱鍥藉唴浜夊ず闈掕捒璧勬簮銆侀潚钂跨礌鐢熶骇鍜屽嚭鍙g殑鏃犲簭绔炰簤鐨勭姸鎬佷篃鍦ㄥ嚭鐜般€傚姞涓婃鏃?/span>鐢卞浗瀹跺崼鐢熼儴鍜屽浗瀹跺尰鑽鐞嗗眬鎴愮珛鐨?ldquo;闈掕捒绱犳寚瀵煎鍛樹細”锛屽湪瀹屾垚钂跨敳閱氥€侀潚钂跨惀閰拰闈掕捒绱犳爴鍓傚浗鍐呰嵂鐗╂敞鍐屽皻鏈浆鍏ュ競鍦哄紑鍙戦樁娈典箣闄咃紝浜?/span>1988骞?/span>6鏈?/span>13鏃ュ鍛婄粨鏉燂紝鏈夊叧闈掕捒绱犵被鎶楃枱鑽殑鐮旂┒寮€鍙戝伐浣滐紝缁х画绾冲叆鍚勬湁鍏抽儴闂ㄣ€佸崟浣嶈嚜琛岀鐞嗐€傚叏鍥藉師鏈夌殑绉戙€佸伐銆佽锤涓夌粨鍚堢殑閾炬潯鍏崇郴涔熺敱姝よ€屼腑鏂€?o:p>

鍦ㄩ潚钂跨礌鎸囧濮斿憳浼氭挙閿€鍚庯紝濡備笉鍙婃椂閲囧彇鏈夋晥鎺柦锛屽緢濂藉湴鍔犱互缁勭粐鍜屽紩瀵硷紝鍔垮繀閫犳垚鎭舵€х珵浜夌殑娣蜂贡灞€闈€傚叾鍚庢灉灏嗕娇鎴戝浗闈掕捒绱犵殑鐮斿彂鍜岄潚钂跨礌浜т笟锛屽湪鍥介檯涓婄敱鍘熸潵鐨勪紭鍔胯€屽彉涓哄姡鍔匡紝鍥藉涔熷皢钂欏彈缁忔祹鎹熷け銆?/span>

1987骞?/span>11鏈堬紝鍥藉绉戝閮功瑷€鍓富浠诲拰鍥藉鍖昏嵂绠$悊灞€

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閭撹搲浠?/span>鏁欐巿棰嗗鐨勬姉鐤熻嵂鍖栧鍚堟垚瀹わ紝浠?/span>523椤圭洰绉戠爺宸ヤ綔寮€濮嬶紝渚垮悎鎴愪簡澶ч噺鐨勬柊鍖栧悎鐗╋紝浠庝腑绛涢€夊嚭浜嗘柊鐨勬姉鐤熷寲鍚堢墿鏈姶閱囥€傝瀹ょ殑鏉庣鏋楃爺绌跺憳绛変汉鍚堟垚浜嗙7閰歌悩閰氬柟銆傝繖涓や釜鏂板寲鍚堢墿鐢辨粫缈曞拰銆佸懆涔夋竻銆佺劍宀嵖銆佺帇浜戠幉绛夌爺绌朵汉鍛樺畬鎴愪簡鑽銆佽嵂鐞嗐€佷复搴婄殑鐮旂┒鍚庯紝閮借鎵瑰噯涓轰竴绫绘柊鑽紱鏈姶閱囪幏寰楀浗瀹跺彂鏄庝竴绛夊锛岀7閰歌悩閰氬柟鑾峰緱鍥藉鍙戞槑浜岀瓑濂栥€傞潚钂跨礌浠ュ強杩欎袱涓柊鑽紝閮芥槸杩勪粖鎴戝浗鏂拌嵂鏈€楂樼殑鍙戞槑濂栭」銆傝繖浜涙柊鑽拰闈掕捒绱狅紝涓哄悗鏉ユ垜鍥介潚钂跨礌澶嶆柟棰嗗厛涓栫晫鎻愪緵浜嗗潥瀹炵殑鐗╄川鍩虹銆?/span>

1990骞达紝鍐涗簨鍖诲绉戝闄㈠井鐢熺墿娴佽鐥呯爺绌舵墍锛岀巼鍏堟垚鍔熷紑鍙戜簡钂跨敳閱?mdash;鏈姶閱囧鏂癸紝鑾峰浗瀹舵柊鑽敞鍐屻€?/span>20涓栫邯90骞翠唬锛屼粬浠敤闈掕捒绱犲拰纾烽吀钀橀厷鍠圭粍鎴愪簡鍙︿竴涓柊澶嶆柟锛屼篃鑾峰緱鍥藉鏂拌嵂娉ㄥ唽銆傝捒鐢查啔—鏈姶閱囧鏂逛笌鐟炲+璇哄崕鍏徃锛堝師涓烘苯宸?mdash;鍢夊熀鍏徃锛夊悎浣滐紝璇哄崕鍏徃鎶曞叆澶ч噺璧勯噾锛屾寜鍥介檯鏂拌嵂鐮斿彂鏍囧噯閲嶆柊杩涜浜嗙爺绌惰瘎浠凤紝浣胯澶嶆柟鏂拌嵂浜?/span>2002骞磋杞藉叆WHO鍩烘湰鑽墿鐩綍銆傚畠鏍囧織鐫€缁ч潚钂跨礌鍙婂叾琛嶇敓鐗╀箣鍚庯紝鎴戝浗闈掕捒绱犲鏂圭爺绌舵妧鏈張鎴愪负鍥介檯鍏堣繘姘村钩鐨勪唬琛ㄣ€?/span>

1981骞村湪鍖椾含涓捐鐨?/span>WHO SWG锛?/span>CHEMAL闈掕捒绱犲強鍏惰鐢熺墿瀛︽湳璁ㄨ浼氫笂锛屼笌浼氫汉鍛樺洿缁曟媴蹇冮潚钂跨礌涓€鏃﹁骞挎硾搴旂敤鍙兘浜х敓鎶楄嵂鎬х殑闂灞曞紑浜嗚璁恒€傚啗浜嬪尰瀛︾瀛﹂櫌寰敓鐗╂祦琛岀梾鐮旂┒鎵€鐨勭鎶€浜哄憳锛屼互鏁忛攼鐨勭溂鍏夊拰鎬濊矾锛屾妸闃叉鍜屽欢缂撻潚钂跨礌绯诲垪鍙婂叾浠栨柊鎶楃枱鑽骇鐢熸姉鑽€э紝鎴栨彁楂樺凡鍑虹幇鎶楄嵂鎬х殑鑽墿鐤楁晥锛屼綔涓轰竴涓繁鍏ョ殑鐮旂┒鏂瑰悜锛屽紑绔嬩簡鐮旂┒璇鹃銆?/span>

浠ュ懆涔夋竻銆佹粫缈曞拰涓鸿棰樿礋璐d汉鐨勭爺绌跺皬缁勶紝鍦ㄦ棭鏈熸彺澶栧簲鎬ラ闃插鏂圭殑鍩虹涓婏紝浜?/span>20涓栫邯80骞翠唬鍒濆嵆寮€灞曚簡闈掕捒绱犲強鍏惰鐢熺墿涓庡叾浠栨姉鐤熻嵂缁勬垚澶嶆柟鐨勬帰绱㈢爺绌躲€備粬浠湪涓?/span>WHO鐨勫悎浣滀腑琚嫆缁濄€佸苟琚柇瑷€“浣犱滑娌℃湁鐮旂┒澶嶆柟鑽墿鐨勬潯浠跺拰鑳藉姏”鐨勬儏鍐典笅锛?/span>1982骞村湪鑾峰緱闈掕捒绱犳寚瀵煎鍛樹細缁欎簣璧勯噾璧勫姪鍚庯紝寤虹珛浜嗘柊鐨勫疄楠屾ā鍨嬶紝寮€灞曢潚钂跨礌鍙婂叾琛嶇敓鐗╀笌SP銆佹湰鑺撮唶绛夎嵂鐗╅厤浼嶅鏁堢殑瀹為獙锛屼粠涓€夊嚭钂跨敳閱氫笌鏈姶閱囩殑閰嶄紞浣滀负涓昏鐨勭爺绌惰棰?/span>[54]銆?/span>

姝e鍓嶉潰鎵€鎻愬埌鐨勶紝钂跨敳閱氭槸鐢变腑鍥界瀛﹂櫌涓婃捣鑽墿鐮旂┒鎵€涓庢槅鏄庡埗鑽巶鍚堜綔鐮斿彂鐨勬姉鐤熻嵂锛?/span>1981骞村垵閫氳繃閴村畾锛屾槸鐢辨垜鍥借嚜涓荤爺鍙戠殑涓€绫绘柊鑽€傛湰鑺撮唶涔熸槸鎴戝浗鑷富鐮斿彂鐨勶紝鍏锋湁鏂扮殑鍖栧缁撴瀯鐨勬姉鐤熸柊鑽紝涓庢隘鍠规棤浜ゅ弶鎶楄嵂鎬э紝浜?/span>1989骞磋幏鍥藉涓€绫绘柊鑽瘉涔︼紝鍏堢敱鏄嗘槑鍒惰嵂鍘傜敓浜э紝鍚庢敼鐢辨禉姹熸柊鏄屽埗鑽巶鐢熶骇銆傛湰鑺撮唶浣滀负娌荤枟鑽樉鏁堣緝鎱紝涓庤捒鐢查啔绛夐€熸晥鑽墿閰嶄紞锛屼紭鍔夸簰琛ワ紝骞舵樉绀轰簡鏄庢樉鐨勫鏁堜綔鐢ㄣ€?/span>

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1989骞达紝瓒婂崡杩涘叆缁忔祹鏀归潻寤鸿锛屽ぇ閲忎汉鍙f祦鍔紝鐤熺柧澶氬鏆村彂娴佽銆傝秺鍗楃殑鎭舵€х枱鎶楄嵂鎬т弗閲嶏紝鍑虹幇澶ч噺閲嶇棁鐤熺柧鐥呬汉姝讳骸銆傚師涓虹編鍐涙悶鎶楃枱鑽爺绌剁殑鍖荤敓鍩烘€?/span>·闃垮痉璇猴紙Keith Arnold锛夛紝姝ゆ椂鏈嶅姟浜庣憺澹綏澹埗鑽叕鍙革紝姝e湪鑳″織鏄庡競寮€灞曠敳姘熷柟鐨勪复搴婄爺绌躲€備粬鏃╁湪20涓栫邯80骞翠唬灏变笌鏉庡浗妗ョ爺绌跺皬缁勬湁杩囦氦寰€锛屾垚涓哄ソ鏈嬪弸銆備粬杩樻浘涓撶▼鍒版捣鍗楀矝鏉庡浗妗ュ皬缁勭殑鐮旂┒鍩哄湴鍙傝锛岄潪甯镐簡瑙d粬浠殑鐮旂┒宸ヤ綔銆傚洜姝わ紝浠栧悜瓒婂崡鑳″織鏄庡競Cho Ray鍥藉鍖婚櫌闄㈤暱

1991骞达紝鏉庡浗妗ュ皬缁勫簲閭€鍓嶅線鑳″織鏄庡競锛屾寚瀵肩敤闈掕捒绱犳晳娌婚噸鐥囩枱鐤炬偅鑰呫€傚綋鏃朵腑瓒婁袱鍥藉皻鏈仮澶嶆甯稿叧绯汇€傝秺鍗楀崼鐢熼儴閮ㄩ暱浠ョ浜哄悕涔夛紝鍒板棣嗗悜浠栦滑鍜ㄨ鑹瓥銆傛潕鍥芥ˉ寤鸿锛屽湪瓒婂崡鍏ㄥ浗鐤熺柧娴佽鍖猴紝绔嬪嵆骞挎硾閲囩敤骞胯タ妗傛灄鍒惰嵂鍘傜敓浜х殑闈掕捒鐞ラ叝浣滀负娌荤枟鑽€傛灉鐒讹紝绗簩骞磋秺鍗楃殑鐤熺柧鐥呬汉姝讳骸浜烘暟鏄捐憲涓嬮檷锛岃€屽箍瑗挎鏋楀埗鑽巶闈掕捒鐞ラ叝鐨勯攢鍞噺鍒欐€ュ墽涓婂崌銆備袱骞村悗锛岃秺鍗楀ぇ琛楀皬宸风殑灏忓晢閾洪噷锛屾様鏃ョ殑濂庡畞宸辫闈掕捒鐞ラ叝鎵€浠f浛銆?/span>

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褰?/span>CV8鍦ㄨ秺鍗楁敞鍐屻€佺敓浜х殑鏃跺€欙紝WHO椹昏秺銆佹煬銆佽€佺殑浠h〃Dr. Allan Schapira涔熷瘑鍒囧叧娉ㄧ潃姝や簨銆?/span>1998骞达紝浠栦笓绋嬭闂簡骞垮窞涓尰鑽ぇ瀛︾儹甯﹀尰瀛︾爺绌舵墍锛岃缁嗚€冨療浜嗚ВCV8鐨勭爺鍒舵儏鍐靛拰涓村簥璇勪环鐨勭粨鏋溿€?/span>

2000骞村垵锛?/span>WHO/TDR閭€璇锋潕鍥芥ˉ浠ヤ复鏃堕【闂韩浠藉嚭甯湪娉板浗锛堟竻杩堬級涓捐鐨勮璁烘姉鑽€ф伓鎬х枱鐤鹃槻娌荤殑浼氳锛岃浠栦笓棰樻姤鍛?/span>CV8鐨勭爺鍒舵儏鍐点€傚悓骞达紝搴?/span>WHO/TDR鐨勮姹傦紝涓庝粬浠璁簡CV8鎶€鏈繚瀵嗗崗璁紝鎶?/span>CV8鐮旂┒璧勬枡鎻愪氦WHO/TDR杩涜璇勪环銆?/span>2001骞达紝WHO/TDR鍚戞潕鍥芥ˉ鎻愬嚭鏀硅繘CV8閰嶆柟鐨勬剰鍚戙€傚悓骞?/span>5鏈堬紝Dr. Allan Schapira鍜岃嫳鍥界墰娲ュぇ瀛︾殑Dr. Jeremy鍒板箍宸炲晢璋堟敼杩涢厤鏂圭殑鍏蜂綋寤鸿銆傛鏃讹紝鏉庡浗妗ュ凡缁忎负浠栦滑鍑嗗濂芥敼杩涘悗鐨勬柊澶嶆柟鏍峰搧銆備护浠栦滑鎰熷埌鎰忓鐨勬槸鏀硅繘鍚庣殑鎴愬垎鍜岄厤姣旂珶鐒朵笌浠栦滑姝h鎻愬嚭鐨勫缓璁浉涓€鑷达紒浠栦滑鍏卞悓鎶婃柊澶嶆柟鏆傚畾鍚嶄负Artekin锛屽苟甯﹁蛋浜?/span>200涓梾渚嬬殑娌荤枟鑽紝杩斿洖鑻卞浗鐗涙触澶у椹昏秺鍗楃殑鐮旂┒鍩哄湴杩涜涓村簥璇曢獙瑙傚療銆?/span>

鐢变簬Artekin鏂板鏂规垚鏈€犱环姣旇緝浣庯紝Dr. Allan Schapira瀵瑰叾鏋佷负鍏虫敞銆傚敖绠″綋鏃剁憺澹鍗庡叕鍙哥殑Coartem锛堣捒鐢查啔—鏈姶閱囧鏂癸級宸茬粡琚浇鍏?/span>WHO鐨勫熀鏈嵂鐗╃洰褰曪紝浣嗙敱浜庡敭浠蜂粛杈冮珮锛屼粬甯屾湜鏈潵鐨?/span>Artekin鑳藉杩涘叆鍏珛鍖荤枟鏈烘瀯浠ュ彇浠f隘鍠癸紝瑙e喅闈炴床鐤熺柧鍥犳姉鑽€ф棩瓒嬩弗閲嶈€屽鑷寸梾姝荤巼鍜屽彂鐥呯巼鏈夊鏃犲噺鐨勯毦棰樸€傚悗鏉?/span>Dr. Allan Schapira琚彁鍗囦负瑗垮お鍖虹枱鐤鹃【闂€佸湴鍖轰唬琛紝杩涜€屾垚涓?/span>WHO鎬婚儴鍒嗙鐤熺柧鎺у埗鐨勮鍛樸€?/span>2001骞?/span>11鏈堬紝浠栦富鎸佸彫寮€WHO锛堜笂娴凤級鎶楃枱鑽彂灞曚細璁悗锛岀珛鍒诲張绛瑰垝鍦?/span>2002骞?/span>3鏈堝彫寮€WHO锛堝箍宸烇級鍔犲揩Artekin鍥介檯鏍囧噯鍖栫殑鐮旇浼氥€傝繖鏄户1981骞?/span>11鏈堝拰1989骞?/span>5鏈堬紝WHO鐤熺柧鍖栫枟绉戝宸ヤ綔缁?/span>鍦ㄥ寳浜妇琛屼袱娆℃鐮旇浼氬悗锛屽湪涓浗鍙堜负闈掕捒绱犳姉鐤熻嵂涓撻棬涓捐鐨勪細璁€傚挨鍏舵槸2002骞?/span>4鏈堝湪骞垮窞鍙紑鐨勫姞蹇弻姘㈤潚钂跨礌锛嶇7閰稿搶鍠圭墖鍥介檯鏍囧噯鍖栫爺璁ㄤ細锛岀壒璇锋潵12鍚嶅浗闄呮湁鍏虫柟闈㈢殑鏉冨▉涓撳锛屼负鎺ㄨ繘鍔犲揩Artekin鐨勫浗闄呮敞鍐岋紝鍒楀叆WHO鐨勫熀鏈嵂鐗╃洰褰曪紝鎴愪负鍏ㄧ悆鐤熷尯涓€绾挎姉鐤熻嵂鍏卞悓鍑鸿皨鍒掔瓥銆?/span>

涓轰簡WHO锛堝箍宸烇級鍔犲揩Artekin鍥介檯鏍囧噯鍖栫殑鐮旇浼氱殑鍙紑锛?/span>Dr. Allan Schapira浼氳浜嗗箍宸炲競鏋楀厓鍜屽壇甯傞暱鍙婂浗瀹惰嵂鍝佺洃鐫g鐞嗗眬鍜屽浗瀹朵腑鍖昏嵂绠$悊灞€鐨勬湁鍏抽瀵笺€備负浜嗗垱閫?/span>Artekin鐨?/span>GMP鐢熶骇鏉′欢锛屼粬涓撶▼闄悓缇庡浗鑽吀濮斿憳浼氾紙USP锛夌殑GMP涓撳 ---- 缇庡浗USPDQI椤鹃棶銆?/span>FDA璐熻矗鑰冨療鍥藉宸ュ巶鐨勫墠璐熻矗浜哄郊寰楋紙Peter D. Smith锛?/span>鍒板箍涓滈『寰风幆鐞冨埗鑽巶鑰冨療锛屽湪涓ゅ勾鍐呰繛缁鏌ヤ簡3娆★紝鐩村埌Peter D. Smith鍐欏嚭璇勪环锛岃涓?ldquo;璇ュ巶瀹屽叏鍙互鎸?/span>GMP鏉′欢鎵挎媴鐢熶骇瓒冲浣跨敤鐨?/span>Artekin鐨勭敓浜т换鍔?rdquo;銆備负浜嗘帹杩?/span>Artekin鐨勫浗闄呮爣鍑嗗寲鐮斿彂锛屼粬鍙堝缓璁潕鍥芥ˉ涓庤嫳鍥界墰娲ュぇ瀛?/span>N. White鏁欐巿鍜?/span>WHO/TDR鍚堜綔锛岃仈鍚堢敵璇锋瘮灏?middot;鐩栬尐璧勫姪鐨勫叏鐞冪枱鐤鹃闄╁熀閲戯紙MMV锛夛紝璇ラ」鐩幏寰椾簡MMV鐨?/span>350涓囩編鍏冪殑璧勫姪銆?/span>

鑷?/span>2002骞村簳锛?/span>Artekin鍦ㄥ叏鐞冨悇涓祦琛屽尯涓庡寘鎷?/span>Coartem鍦?/span>鍐呯殑鍏朵粬鎶楃枱鑽鐓х殑璇曠敤涓紝鍏辫瀵熶簡5000涓梾渚嬶紝鍙栧緱浜嗘不鎰堢巼楂樿揪97%浠ヤ笂鐨勬晥鏋溿€傜患鍚堣鑽殑鐤楁晥銆佷笉鑹弽搴斻€佹垚鏈环鏍笺€佷娇鐢ㄦ柟渚垮害绛夛紝琚涓烘槸鐩墠浼樼偣鍏ㄩ潰鐨勪竴涓姉鐤熻嵂銆?/span>

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