| 医学翻译案例
摘要：目的探讨香丹注射液抗缺氧有效部位。方法采用小鼠常压耐缺氧实验，基于正交设计，建立复方药效学预测模型，模拟偏倚由2种散点图结合评价；并经实验验证，确定香丹注射液抗缺氧有效部位。结果本文所建立的复方预测模型可以对复方不同组合进行药效预测，其中112只小鼠（占93.3%）的PE%≤25%。结论通过模型预测和实验验证，5个配伍组的药效均优于原方，其中ADE效果{zj0}。
Abstract: Objective: To investigate the anti-hypoxia active
fraction of Xiangdan Injection. Methods: Anti-hypoxia experiment
under normal pressure with mice was adopted on the basis of
orthogonal design, prediction pharmacodynamics model of TCM
prescriptions was established, and the simulation bias was
evaluated by combining two scatterplots. The anti-hypoxia active
fraction of Xiangdan Injection was determined by experiments.
Results: the prediction model of TCM prescriptions established in
this study can predict the drug actions for different formulas, and
PE%≤25% was observed in 112 mice (93.3%). Conclusion: As indicated
in model prediction and experimental confirmation, the
pharmacodynamic actions of the 5 formulas are all superior to that
of the original formula, and ADE has the best effect.
关键词：香丹注射液；有效部位；药效；模拟
Key words: Xiangdan Injection; active fraction; pharmacodynamic
action; simulation
香丹注射液也称复方丹参注射液，是由丹参的水提液和降香的饱和芳香水加工配制而成的中药注射液，具有xx化瘀、扩张血管与增进冠状动脉血量的的功效，临床上主要用于xx冠心病、心脏病和脑血管疾病。由于是中药复方，成分复杂，临床上偶有不良反应发生。本文拟寻找其有效组分，并以有效组分为xx进行中药复方二次开发模式的探讨。
Xiangdan Injection is also named compound salvia injection, a
Chinese herbal injection with salvia extract and saturated solution
of rosewood, with functions of promoting blood flow to dissipate
stasis, dilating blood vessels and increasing blood volume in
coronary arteries. In clinics, it is mainly applied to treat
coronary diseases, heart diseases and cerebral vascular diseases.
Because it is a TCM prescription, the ingredients are complex, with
occasionally adverse effects. This study is designed to search its
active ingredients, and investigate the re-development of TCM
prescription based on the effective ingredients.
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抗苗勒管xx（anti-mullerian hormone, AMH）又称苗勒管抑制物质（mullerian
inhibitory substance, MIS），是转化生长因子β（transforming growth fatorsβ,
TGF-β）超家族的成员之一，只在性腺产生，主要由窦前及小窦卵泡的颗粒细胞产生。既往研究表明AMH与小窦卵泡数显著相关，整个月经周期改变很小，比基础血清促卵泡刺xx（FSH），抑制素B和雌二醇（E2）更准确、更早、在月经任何时期都能反映卵巢储备功能[1,
2, 3]。多囊卵巢（polycystic ovary,
PCO）妇女的血清AMH浓度比正常妇女明显增高，有PCO表现比无PCO表现的WHO无型无排卵不孕妇女血清AMH明显增高，提示AMH增高与卵巢卵泡数过多有关[4-7]。由于大部分PCO妇女的卵泡停滞在2-9mm的小窦卵泡阶段，无优势卵泡形成，而大于9mm的卵泡AMH生成很少，这对优势卵泡的选择可能是必需的，研究者推测PCO妇女增高的AMH可能与卵巢卵泡生长停滞有关[4,
6-8]。然而部分PCO妇女仍有正常排卵，这部分患者的血清AMH水平是否有变化还不清楚。血清AMH水平与卵泡生长停滞是否相关值得进一步研究。
AMH (Anti-mullerian hormone) is also named as MIS (mullerian
inhibitory substance), and it is a member of transforming growth
factor β (TGF-β) super family. It only comes from the gonad, and is
mainly produced by granulose cells of preantral and small antral
follicles. The former researches showed that AMH was obviously
relevant with the number of small antral follicles, and the whole
menstrual cycle changed little; AMH was more accurate, earlier than
FSH, inhibin B and E2, and could reflect reserve function[1, 2, 3]
of ovary at any time during menstruate. Serum and AMH concentration
of the women with PCO is obviously higher than the normal women and
serum AMH of WHO II anovulatory and infertile women with PCO is
obviously higher than those without PCO, indicating that the
increase of AMH is relevant with too many follicles [4-7].
Follicles of most women with PCO stay in the stage of small antral
follicles with the diameter of 2-9mm, and they do not give birth to
any superior follicle. The follicles with the diameter of over 9mm
give birth to less AMH, which may be necessary for the choice of
superior follicles. Researchers speculated that increased AMH of
the women with PCO might be relevant with ovarian follicular arrest
[4, 6-8]. However, some women with PCO are still normoovulatory,
and the changes of their serum and AMH levels have not been
acquainted clearly. Therefore, it is valuable to further study the
correlation between serum AMH level and follicular arrest.
为了探索AMH在卵泡生长过多和发育停滞中的作用，我们采用酶联免疫吸附法（enzyme-linked immunosorbent
assay,
ELISA）比较了正常妇女和PCO妇女之间，以及排卵正常与排卵障碍的PCO妇女之间的血清及排卵前卵泡的卵泡液(follicular
fluid, FF) 的AMH水平。分析其与PCO临床特征的相关关系，对AMH与PCO不孕患者有无排卵的相关性进行探讨。
To explore the effect of AMH in too much growth of ovarian
follicles and follicular arrest, we adopt ELISA (enzyme-linked
immunosorbent assay) to compare serum and pre-ovulation FF AMH
levels between normal women and the women with PCO, and between
normoovulatory and anovulatory women with PCO. We analyze the
relationship between them and PCO clinical features and discuss the
correlation between AMH and the ovulation of the infertile women
with PCO.
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