鈶?/span>
鍥涖€佹绱㈢粨鏋?/span>锛?/span>
1銆佹绱㈢粨鏋滄€昏〃
2銆佸悇妫€绱㈠伐鍏锋绱㈡儏鍐典竴瑙堣〃锛?o:p>
|
妫€绱㈠伐鍏?o:p>
|
妫€绱㈠勾闄愶紙璧锋骞达級
|
妫€绱㈡枃鐚€婚噺
|
妫€鍑烘枃鐚噺
|
瀵嗗垏鐩稿叧鏂囩尞
|
|
CBM-disc
|
1978-2008
|
487涓囦綑
|
30+
|
2
|
|
CHKD璺ㄥ簱妫€绱㈠钩鍙?o:p>
|
1994-2008
|
600涓囦綑
|
30+
|
2
|
|
鍥藉绉戞妧鎴愭灉搴?o:p>
|
1999-2008
|
2涓囦綑
|
0
|
0
|
|
鍥藉绉戞妧鍥句功鏂囩尞涓績
|
1981-2008
|
2300涓囦綑
|
30+
|
2
|
|
INTERNET-PUBMED
|
1966-2008
|
1600涓囦綑
|
30+
|
0
|
3銆佺浉鍏虫枃鐚?o:p>
1. 鍏崇繝钀? 鍛ㄥ濡? 鏉庢案浼?鏉窞甯傜涓変汉姘戝尰闄㈢毊鑲ょ, 310009) . 浜洪叒姘ㄩ吀閰舵姉鍘熻〃浣嶈偨鐨勮〃杈俱€佺函鍖栧強鍦ㄧ櫧鐧滈鎮ｈ€呬腑鐨勬姉鍘熸€ф娴?/span>. 涓崕鍖诲鏉傚織 2007; 87(34): 2408-2411
鍏崇繝钀嶇瓑鎴愬姛琛ㄨ揪浜嗕汉閰皑閰搁叾鎶楀師琛ㄤ綅鑲?span lang="EN-US">,鍏跺湪鐧界櫆椋庢偅鑰呰娓呬腑鍏锋湁鎶楀師鎬с€傚簲鐢ㄥ嚌鑳跺垎鏋愮郴缁熷垎鏋愯泲鐧借〃杈鹃噺鍙戠幇,鐩殑铔嬬櫧鐨勮〃杈鹃噺鍗犺弻浣撴€昏泲鐧界殑70%銆傝瀺鍚堣泲鐧界粡杩囪胺鑳辫嫹鑲?span lang="EN-US">S-
杞Щ閰惰瘯鍓傜洅绾寲鍚?span lang="EN-US">,鍏惰泲鐧界函搴﹁揪90%浠ヤ笂銆?span lang="EN-US">100渚嬬櫧鐧滈鎮ｈ€呬腑64渚嬭娓呬笌铔嬬櫧缁撳悎鍙嶅簲鍛堥槼鎬?span lang="EN-US">,30鍚嶆甯镐汉琛€娓呯粨鍚堝弽搴斿潎鍛堥槾鎬с€?span lang="EN-US">
2. 鍏崇繝钀? 鏉庢案浼? 灏夋檽鍐紙鏉窞甯傜涓変汉姘戝尰闄㈢毊鑲ょ, 310009锛? 浜洪叒姘ㄩ吀閰舵姉鍘熻〃浣嶈偨鐨勮〃杈俱€佺函鍖栧強鐢熺墿瀛︽椿鎬у垎鏋? 涓崕鐨偆绉戞潅蹇?span style="mso-spacerun: yes"> 2007; 40(3): 139-142
3. 闄堟睙; 娑傚僵闇? 鐜嬪ぇ鍏夛紙澶ц繛鍖荤澶у绗簩闄勫睘鍖婚櫌鐨偆绉?杈藉畞澶ц繛116027锛? 鐧界櫆椋庡鑹插尯榛戠礌缁嗚優鐗瑰紓鎬ф姉鍘熻〃杈剧殑鐮旂┒.涓村簥鐨偆绉戞潅蹇?span style="mso-spacerun: yes"> 2006; 35(9): 566-568
闄堟睙绛?/span>鐮旂┒浜嗙櫧鐧滈澶嶈壊鍖洪粦绱犵粏鑳炲垎甯冨強gp100銆侀叒姘ㄩ吀閰?span lang="EN-US">(TYR)绛夋姉鍘熺殑琛ㄨ揪銆傚彂鐜拌壊绱犺劚澶辨枒澶勬湁鍔熻兘榛戠礌缁嗚優缂哄け銆傚鑹插尯鍐呭彲瑙侀粦绱犵粏鑳?span lang="EN-US">,鍏剁粨鏋勩€佸姛鑳界殕瀹屾暣,鏁扮洰涓庢甯镐汉鏃犳槑鏄惧樊鍒€傚鑹插尯榛戠礌缁嗚優鍙兘鏉ユ簮浜庢瘺鍥婄粍缁?span lang="EN-US">.浜﹀彲鑳芥潵婧愪簬鑹茬礌鑴卞け鏂戣竟缂樻甯搁粦绱犵粏鑳炪€?span lang="EN-US">TRP-1鐨勯珮琛ㄨ揪鍙兘瀵艰嚧澶嶈壊鍖洪粦绱犵粏鑳炵殑褰㈡€佸紓甯搞€?span lang="EN-US">
4. 鏉庡环鎱?span lang="EN-US">; 楂樺ぉ鏂?span lang="EN-US">; 鏉庢槬鑻?(绗洓鍐涘尰澶у瑗夸含鍖婚櫌鍏ㄥ啗鐨偆鎬х梾涓績 710032). 鎶楅叒姘ㄩ吀閰剁浉鍏宠泲鐧?span lang="EN-US">-1B缁嗚優琛ㄤ綅鍖哄鍏嬮殕鎶椾綋鐨勫埗澶囧強閴村畾. 缁嗚優涓庡垎瀛愬厤鐤鏉傚織 2003.05.18; 19(3): 263-265
鏉庡环鎱х瓑鍒跺澶氬厠闅嗘姉浣撳苟鍒濇鐢ㄤ簬TRP-1鎶楀師琛ㄤ綅鍖虹殑鐮旂┒,涓虹櫧鐧滈銆佹伓鎬ч粦绱犵槫鐨勫厤鐤不鐤楁彁渚涘疄楠屼緷鎹€傚湪澶ц偁鏉嗚弻涓〃杈?span lang="EN-US">PRSETA/TRP-1铻嶅悎铔嬬櫧,鐢ㄦ墍鑾峰緱鐨勮泲鐧藉厤鐤柊瑗垮叞鐧藉厰寰楀埌澶氬厠闅嗘姉浣?span lang="EN-US">,骞剁敤ELISA銆?span lang="EN-US">Western-blot鏂规硶杩涜姝ゆ姉浣撶殑閴村畾銆傜粨鏋滄樉绀烘鎶椾綋鍙敤浜?span lang="EN-US">TRP-1 B缁嗚優琛ㄤ綅鑲芥鐨勮繘涓€姝ョ爺绌躲€?span lang="EN-US">
5. 璋煄; 鏈辨枃鍏?span lang="EN-US">; 椴佷弗(鍗椾含鍖荤澶у绗竴闄勫睘鍖婚櫌鐨偆绉?span lang="EN-US"> 210029). 鐧界櫆椋庣毊鎹熼粦绱犵粏鑳?span lang="EN-US">HMB-45銆侀叒姘ㄩ吀閰跺強鍏剁浉鍏宠泲鐧?span lang="EN-US">1鐨勫厤鐤粍鍖栫爺绌?span lang="EN-US">. 涓村簥鐨偆绉戞潅蹇?span lang="EN-US"> 2003.07.05; 32(7): 376-378
璋煄绛?/span>鐮旂┒浜嗙櫧鐧滈鐧芥枒澶勯粦绱犵粏鑳炲垎甯冨強閰皑閰搁叾(TYR)绛夋爣璁板垎瀛愮殑琛ㄨ揪鎯呭喌銆傚鍚哥柋娉曟墍鍙栫櫧鏂戠毊鑲や互鍏嶇柅缁勫寲鏌撹壊璇嗗埆TYR銆侀叒姘ㄩ吀閰剁浉鍏宠泲鐧?span lang="EN-US">1(TRP1)鍜?span lang="EN-US">HMB-45,浠?span lang="EN-US">Mias99褰╄壊鍥惧儚鍒嗘瀽杞欢瀹氶噺鍥惧儚鍒嗘瀽闃虫€ц〃杈剧殑寮哄急銆傜櫧鏂戝浠嶇劧鏈夐粦绱犵粏鑳炪€傛畫瀛橀粦绱犵粏鑳炴爲绐佸洖缂┿€佹暟鐩彉灏?span lang="EN-US">,鑰屼笖榛戠礌缁嗚優涓粦绱犵粏鑳炴爣璁板垎瀛愯〃杈惧紓甯搞€?span lang="EN-US">
6. 宕旂幉; 楂樺ぉ鏂?span lang="EN-US">; 鑻忔尟鍏?(瑗垮畨绗洓鍐涘尰澶у瑗夸含鍖婚櫌鍏ㄥ啗鐨偆鎬х梾涓績 710032). 鐧藉噣鍐插墏鍚堝苟杞Щ鍥犲瓙鍚嵂琛€娓呭榛戠礌缁嗚優澧炴畺鍜岄叒姘ㄩ吀閰剁殑婵€娲讳綔鐢?span lang="EN-US">. 涓浗缇庡鍖诲 2002.06.01; 11(3): 208-210
宕旂幉绛?/span>鎺㈣浜嗕腑鑽鏂瑰埗鍓?ldquo;鐧藉噣鍐插墏鍚堝苟杞Щ鍥犲瓙”瀵圭櫧鐧滈娌荤枟鐨勪綔鐢ㄦ満鐞嗐€傚彂鐜颁腑鑽櫧鍑€鍐插墏鍚堝苟杞Щ鍥犲瓙瀵归粦绱犵粏鑳炵殑澧炴畺鍙婇叒姘ㄩ吀娲绘€у叿鏈夋槑鏄句績杩涗綔鐢ㄣ€?span lang="EN-US">
7. Song,-Y-H; Connor,-E; Li,-Y;et al. The role of tyrosinase in autoimmune vitiligo. Lancet. 1994 Oct 15; 344(8929): 1049-52
Song,-Y-H绛?/span>搴旂敤缁嗚弻鍚堟垚浜洪叒姘ㄩ吀閰?span lang="EN-US">TYR锛屽厤鐤嵃杩规硶妫€娴嬩簡26渚嬬櫧鐧滈鎮ｈ€呰娓?span lang="EN-US">TYR鎶椾綋锛屽叾涓?span lang="EN-US">61%鎶椾綋鍛堥槼鎬?span lang="EN-US">,璇佹槑浜嗛叒姘ㄩ吀閰舵槸鑷韩鍏嶇柅鐧界櫆椋庣殑閲嶈鑷韩鎶楀師銆?/span>
8. Baharav,-E; Merimski,-O; Shoenfeld,-Y; Tyrosinase as an autoantigen in patients with vitiligo. Clin-Exp-Immunol. 1996 Jul; 105(1): 84-8
Baharav,-E绛?/span>鍒╃敤鐧界櫆椋庢偅鑰呰娓呬腑鐨勮嚜韬姉浣擄紝璇佸疄浜嗛叒姘ㄩ吀閰?span lang="EN-US">(TYR)鏄骇鐢熸姉浣撶殑鑷韩鎶楀師锛屽苟涓旇涓烘姉閰皑閰搁叾婊村畾鐜囷紙IgG鎶楅叒姘ㄩ吀閰惰嚜韬姉浣擄級鍙互浣滀负鐤剧梾娲诲姩搴︾殑鏍囧織銆?/span>
9. Okamoto T, Irie RF, Fujii S, Huang SKS, Nizze AJ, Morton DL, Hoon DSB. Antityrosinase related protein-2 immune response in vitiligo patients and melanoma patients receiving active-specific immunotherapy. J Invest Dermatol, 1998, 111: 1034–1039.
Okamoto T绛?/span>鍒╃敤鐧界櫆椋庢偅鑰呰娓呬腑鐨勮嚜韬姉浣擄紝璇佸疄浜嗛叒姘ㄩ吀閰剁浉鍏宠泲鐧?span lang="EN-US">-2(TRP-2)鏄骇鐢熸姉浣撶殑鑷韩鎶楀師銆?/span>
10. Kemp,-E-H; Waterman,-E-A; Gawkrodger,-D-J;et al. Identification of epitopes on tyrosinase which are recognized by autoantibodies from patients with vitiligo. J-Invest-Dermatol. 1999 Aug; 113(2): 267-71
Kemp,-E-H绛?/span>璇佸疄浜?span lang="EN-US">TYR鎶楀師琛ㄤ綅鍒嗗埆浣嶄簬240-255浣嶏紝289-294浣嶏紝295-300浣嶏紝435-447浣嶅拰461-479浣嶆皑鍩洪吀,鑰屼笖鍏剁289-294浣嶅拰295-300浣嶆皑鍩洪吀涓?span lang="EN-US">TRP1鍜?span lang="EN-US">TRP2
鏈夌浉褰撻珮鐨勫悓婧愭€с€?span lang="EN-US">
11. Kemp,-E-H; Waterman,-E-A; Gawkrodger,-D-J; Autoantibodies to tyrosinase-related protein-1 detected in the sera of vitiligo patients using a quantitative radiobinding assay. Br-J-Dermatol. 1998 Nov; 139(5): 798-805
Kemp,-E-H绛夌爺绌舵寚鍑哄湪鐧界櫆椋庤嚜韬姉浣撱€?span lang="EN-US">TRP-1銆?span lang="EN-US">TRP-2瀛樺湪浜ゅ弶鍙嶅簲锛岃〃鏄庡湪杩欎笁绉嶈泲鐧戒腑瀛樺湪涓€绉嶆垨澶氱鐨勫叡鍚屾姉鍘熻〃浣嶃€?span lang="EN-US">
12. Kemp,-E-H; Gawkrodger,-D-J; MacNeil,-S; Detection of tyrosinase autoantibodies in patients with vitiligo using 35S-labeled recombinant human tyrosinase in a radioimmunoassay. J-Invest-Dermatol. 1997 Jul; 109(1): 69-73
Kemp,-E-H绛夋姤閬撲簡搴旂敤纭斁灏勬€ф牳绱?span lang="EN-US">35S鏍囪鐨勯噸缁勪汉閰皑閰搁叾妫€娴嬬櫧鐧滈鎮ｈ€呰嚜韬姉浣撶殑鏀惧皠鍏嶇柅娉曠爺绌躲€傜粨鏋滄樉绀鸿鏂规硶鏄竴绉嶆晱鎰熴€佸畾閲忔娴嬭嚜韬姉浣撹〃浣嶇殑鏂规硶锛屾湁鐩婁簬绾靛悜璋冩煡鍒ゅ畾鐧界櫆椋庝复搴婄棁鐘跺拰閰皑閰搁叾鑷韩鎶椾綋姘村钩涔嬮棿鐨勭浉鍏虫€с€?/span>
浜斻€佹煡鏂板挩璇㈢粨璁?/span>
鏍规嵁鐢宠浜烘煡鏂拌姹傦紝鎻愪緵鐨勬煡鏂板唴瀹癸紝妫€绱㈢敤璇嶄互鍙婄敤涓婅堪妫€绱㈢瓥鐣ワ紝缁忔绱?span lang="EN-US">CBM锛?span lang="EN-US">DISC
銆?/span>CHKD璺ㄥ簱妫€绱㈠钩鍙般€佸浗瀹剁鎶€鎴愭灉搴撱€?/span>鍥藉绉戞妧鍥句功鏂囩尞涓績銆?/span>MEDLINE-PUBMED浜斾釜妫€绱㈠伐鍏?span lang="EN-US">/绯荤粺锛岃秴杩?span lang="EN-US">10骞存椂闂达紝澶х害4970涓囩瘒鏂囩尞锛岄櫎璇鹃鐢虫姤鑰呭鏈鏈夊叧閰皑閰搁叾鐩稿叧铔嬬櫧瀹舵棌琛ㄤ綅宓屽悎鑲藉湪鐧界櫆椋庝腑鐨勪复搴婂簲鐢ㄧ爺绌?/span>鐨勭浉鍏虫枃鐚姤閬?/span>锛?/span>鍏蜂綋鍒嗘瀽濡備笅锛?o:p>
1銆?span style="FONT: 7pt "Times New Roman"">
鐧界櫆椋庣壒寮傛€ф姉鍘熻〃杈剧殑鐮旂┒
璇鹃鐢虫姤鑰呮垚鍔熻〃杈句簡浜洪叒姘ㄩ吀閰舵姉鍘熻〃浣嶈偨,鍏跺湪鐧界櫆椋庢偅鑰呰娓呬腑鍏锋湁鎶楀師鎬с€傚簲鐢ㄥ嚌鑳跺垎鏋愮郴缁熷垎鏋愯泲鐧借〃杈鹃噺鍙戠幇,鐩殑铔嬬櫧鐨勮〃杈鹃噺鍗犺弻浣撴€昏泲鐧界殑70%銆傝瀺鍚堣泲鐧界粡杩囪胺鑳辫嫹鑲?span lang="EN-US">S-杞Щ閰惰瘯鍓傜洅绾寲鍚?span lang="EN-US">,
鍏惰泲鐧界函搴﹁揪90%浠ヤ笂銆?span lang="EN-US">100渚嬬櫧鐧滈鎮ｈ€呬腑64渚嬭娓呬笌铔嬬櫧缁撳悎鍙嶅簲鍛堥槼鎬?span lang="EN-US">,30鍚嶆甯镐汉琛€娓呯粨鍚堝弽搴斿潎鍛堥槾鎬э紙鏂囩尞1銆?span lang="EN-US">2锛夈€?span lang="EN-US">
鍥藉唴鍏朵粬鐩稿叧鏂囩尞锛氶檲姹熺瓑鐮旂┒浜嗙櫧鐧滈澶嶈壊鍖洪粦绱犵粏鑳炲垎甯冨強gp100銆侀叒姘ㄩ吀閰?span lang="EN-US">(TYR)绛夋姉鍘熺殑琛ㄨ揪銆傚彂鐜拌壊绱犺劚澶辨枒澶勬湁鍔熻兘榛戠礌缁嗚優缂哄け銆傚鑹插尯鍐呭彲瑙侀粦绱犵粏鑳?span lang="EN-US">,鍏剁粨鏋勩€佸姛鑳界殕瀹屾暣,鏁扮洰涓庢甯镐汉鏃犳槑鏄惧樊鍒€傚鑹插尯榛戠礌缁嗚優鍙兘鏉ユ簮浜庢瘺鍥婄粍缁?span lang="EN-US">.浜﹀彲鑳芥潵婧愪簬鑹茬礌鑴卞け鏂戣竟缂樻甯搁粦绱犵粏鑳炪€?span lang="EN-US">TRP-1鐨勯珮琛ㄨ揪鍙兘瀵艰嚧澶嶈壊鍖洪粦绱犵粏鑳炵殑褰㈡€佸紓甯革紙鏂囩尞3锛夈€?/span>鏉庡环鎱х瓑鍒跺澶氬厠闅嗘姉浣撳苟鍒濇鐢ㄤ簬TRP-1鎶楀師琛ㄤ綅鍖虹殑鐮旂┒,涓虹櫧鐧滈銆佹伓鎬ч粦绱犵槫鐨勫厤鐤不鐤楁彁渚涘疄楠屼緷鎹€傚湪澶ц偁鏉嗚弻涓〃杈?span lang="EN-US">PRSETA/TRP-1铻嶅悎铔嬬櫧,鐢ㄦ墍鑾峰緱鐨勮泲鐧藉厤鐤柊瑗垮叞鐧藉厰寰楀埌澶氬厠闅嗘姉浣?span lang="EN-US">,骞剁敤ELISA銆?span lang="EN-US">Western-blot鏂规硶杩涜姝ゆ姉浣撶殑閴村畾銆傜粨鏋滄樉绀烘鎶椾綋鍙敤浜?span lang="EN-US">TRP-1 B缁嗚優琛ㄤ綅鑲芥鐨勮繘涓€姝ョ爺绌讹紙鏂囩尞4锛夈€?span lang="EN-US">
鍥藉鐩稿叧鏂囩尞锛?/span>Song,-Y-H绛?/span>搴旂敤缁嗚弻鍚堟垚浜洪叒姘ㄩ吀閰?span lang="EN-US">TYR锛屽厤鐤嵃杩规硶妫€娴嬩簡26渚嬬櫧鐧滈鎮ｈ€呰娓?span lang="EN-US">TYR鎶椾綋锛屽叾涓?span lang="EN-US">61%鎶椾綋鍛堥槼鎬?span lang="EN-US">,璇佹槑浜嗛叒姘ㄩ吀閰舵槸鑷韩鍏嶇柅鐧界櫆椋庣殑閲嶈鑷韩鎶楀師锛堟枃鐚?span lang="EN-US">7锛夈€?/span>Okamoto T绛?/span>鍒╃敤鐧界櫆椋庢偅鑰呰娓呬腑鐨勮嚜韬姉浣擄紝璇佸疄浜嗛叒姘ㄩ吀閰剁浉鍏宠泲鐧?span lang="EN-US">-2(TRP-2)鏄骇鐢熸姉浣撶殑鑷韩鎶楀師锛堟枃鐚?锛夈€?/span>Kemp,-E-H绛?/span>璇佸疄浜?span lang="EN-US">TYR鎶楀師琛ㄤ綅鍒嗗埆浣嶄簬240-255浣嶏紝289-294浣嶏紝295-300浣嶏紝435-447浣嶅拰461-479浣嶆皑鍩洪吀,鑰屼笖鍏剁289-294浣嶅拰295-300浣嶆皑鍩洪吀涓?span lang="EN-US">TRP1鍜?span lang="EN-US">TRP2鏈夌浉褰撻珮鐨勫悓婧愭€?/span>锛堟枃鐚?span lang="EN-US">10锛夈€?/span>Kemp,-E-H绛夌爺绌舵寚鍑哄湪鐧界櫆椋庤嚜韬姉浣撱€?span lang="EN-US">TRP-1銆?span lang="EN-US">TRP-2瀛樺湪浜ゅ弶鍙嶅簲锛岃〃鏄庡湪杩欎笁绉嶈泲鐧戒腑瀛樺湪涓€绉嶆垨澶氱鐨勫叡鍚屾姉鍘熻〃浣?/span>锛堟枃鐚?span lang="EN-US">11锛夈€?/span>
2銆?span style="COLOR: black">鐧界櫆椋庝复搴婄棁鐘跺拰閰皑閰搁叾鑷韩鎶椾綋姘村钩涔嬮棿鐩稿叧鎬х殑鏂囩尞
鍥藉唴鐩稿叧鏂囩尞锛氳碍鍩庣瓑鐮旂┒浜嗙櫧鐧滈鐧芥枒澶勯粦绱犵粏鑳炲垎甯冨強閰皑閰搁叾(TYR)绛夋爣璁板垎瀛愮殑琛ㄨ揪鎯呭喌銆傚鍚哥柋娉曟墍鍙栫櫧鏂戠毊鑲や互鍏嶇柅缁勫寲鏌撹壊璇嗗埆TYR銆侀叒姘ㄩ吀閰剁浉鍏宠泲鐧?span lang="EN-US">1(TRP1)鍜?span lang="EN-US">HMB-45,浠?span lang="EN-US">Mias99褰╄壊鍥惧儚鍒嗘瀽杞欢瀹氶噺鍥惧儚鍒嗘瀽闃虫€ц〃杈剧殑寮哄急銆傜櫧鏂戝浠嶇劧鏈夐粦绱犵粏鑳炪€傛畫瀛橀粦绱犵粏鑳炴爲绐佸洖缂┿€佹暟鐩彉灏?span lang="EN-US">,鑰屼笖榛戠礌缁嗚優涓粦绱犵粏鑳炴爣璁板垎瀛愯〃杈惧紓甯?/span>锛堟枃鐚?span lang="EN-US">5锛夈€?/span>宕旂幉绛?/span>鎺㈣浜嗕腑鑽鏂瑰埗鍓?ldquo;鐧藉噣鍐插墏鍚堝苟杞Щ鍥犲瓙”瀵圭櫧鐧滈娌荤枟鐨勪綔鐢ㄦ満鐞嗐€傚彂鐜颁腑鑽櫧鍑€鍐插墏鍚堝苟杞Щ鍥犲瓙瀵归粦绱犵粏鑳炵殑澧炴畺鍙婇叒姘ㄩ吀娲绘€у叿鏈夋槑鏄句績杩涗綔鐢?/span>锛堟枃鐚?span lang="EN-US">6锛夈€?span lang="EN-US">
鍥藉鐩稿叧鏂囩尞锛?/span>Baharav,-E绛?/span>鍒╃敤鐧界櫆椋庢偅鑰呰娓呬腑鐨勮嚜韬姉浣擄紝璇佸疄浜嗛叒姘ㄩ吀閰?span lang="EN-US">(TYR)鏄骇鐢熸姉浣撶殑鑷韩鎶楀師锛屽苟涓旇涓烘姉閰皑閰搁叾婊村畾鐜囷紙IgG鎶楅叒姘ㄩ吀閰惰嚜韬姉浣擄級鍙互浣滀负鐤剧梾娲诲姩搴︾殑鏍囧織锛堟枃鐚?span lang="EN-US">8锛夈€?/span>Kemp,-E-H绛夋姤閬撲簡搴旂敤纭斁灏勬€ф牳绱?span lang="EN-US">35S鏍囪鐨勯噸缁勪汉閰皑閰搁叾妫€娴嬬櫧鐧滈鎮ｈ€呰嚜韬姉浣撶殑鏀惧皠鍏嶇柅娉曠爺绌躲€傜粨鏋滄樉绀鸿鏂规硶鏄竴绉嶆晱鎰熴€佸畾閲忔娴嬭嚜韬姉浣撹〃浣嶇殑鏂规硶锛屾湁鐩婁簬绾靛悜璋冩煡鍒ゅ畾鐧界櫆椋庝复搴婄棁鐘跺拰閰皑閰搁叾鑷韩鎶椾綋姘村钩涔嬮棿鐨勭浉鍏虫€?/span>锛堟枃鐚?2锛夈€?/span>
缁间笂鎵€杩帮紝涓庡浗鍐呭鏂囩尞瀵规瘮鍒嗘瀽缁撹濡備笅锛?o:p>
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