Abstract Objective : TO investigate the cause and treatment of Infantal Rotaviral enteritis complicated with diaper dermatitis. Methods: Among the Rotaviral enteritis positive patients of our hospital in recent years, analyze the incidence and cause of diaper dermatitis by statistical methods.A total of 318 patients complicated with diaper dermatitis were randomly typed in to treating group and control group, treating group were external applicated with Qing Dai San and talc powder, while control group, treating group were external applicated with Zinc Oxide Ointment. Results: the curing day of two group are 1.01±0.17 (treating group) and 2.12±0.51(control group), with significant difference in statistics (P锛?.01). Conclusion: Infantal Rotaviral enteritis complicated with diaper dermatitis is associated with the course and extent of diarrhea and the misuse of paper diaper. External application of Qing Dai San and talc powder is the effective method to Rotaviral enteritis complicated with diaper dermatitis.